Nagelkerke, A.

c-h 2ax cancer breast 53 bp 1 tumor expression patient c-h 2ax expression damage staining disease progression telomere breast cancer patients c-h 2ax foci genomic instability disease repair oncol receptor progression association oncology bonner wm dna damage staining intensities breast cancers radiotherapy radiother break histone tissue negativity factor c-h 2ax staining intensity instability dna double-strand breaks signi department cohort fication study mutation genomic dna repair signi ficantly breast tumors number group radiation 100 lm / radiotherapy radboud university nijmegen breast cancer bonner telomere length antibody histone h 2ax sccnij 3 tumors constitutive brca 1 bussink j section prognostic relevance result cell lines tumor size phosphorylation dna damage repair gammah 2ax analysis prognostic lesion pathway adjuvant nijmegen nagelkerke hypoxia 39–45 ficant