Geerlings, C.J.

lamivudine patient hepatitis b patients hepatitis plasma level pharmacokinetic group concentration lamivudine plasma levels serum hepatocyte study assay curve range variability therapy detection hbv dna interassay variability group b virus intake response decline difference triphosphate lamivudine 150 mg 1.9 mg /l hepatitis b niesters hgm limit 24 hours wolter 7.5 mg /l method yuen gj lamivudine therapy reference 0.1 mg /l interassay variation process liver table january minute replication chromatography treatment plasma samples hoggard pg lamivudine levels phase plasma levels methanol man ra sample altman plot 42 minutes phosphorylated half-life uptake infection lamivudine concentrations 0.1 niester hplc assay column ic 50 abbott nucleoside hussey ek lamivudine triphosphate reference curve phosphorylated lamivudine absorption pharmacokinetic process chain