Nicolaije, C.

ttd mice osteoblast oxygen differentiation repair formation oxygen tension chapter number phase expression osteoblast differentiation decrease type mice figure matrix periosteal apposition bone formation bone strength tension dna repair culture mineralization wild-type periosteal volume level difference osteoclast effect increase apposition wild-type mice factor study process strength apoptosi trabecular damage oxidative stress marrow analysis stress bone volume thickness probe condition 78 weeks change transcription oxidative tissue growth protein age-related resorption 26 weeks 13 weeks dna damage collagen 52 weeks tibiae mesenchymal analyses trichothiodystrophy metabolism bone mass mechanism adipocyte trabecular bone bone resorption model phenotype gene expression bone marrow group regulation 39 weeks miner