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ttd mice csbm /m mice repair wild-type number wild-type mice volume periosteal apposition animal mouse damage bone strength dna repair level decrease oxidative periosteal osteoblast syndrome difference csbm /m analysis apposition growth photoreceptor retina osteoclast increase strength formation thickness trabecular expression bone volume figure stress study type mice oxidative stress dna damage 78 weeks liver culture 26 weeks 39 weeks change marrow transcription patient perimeter tibiae section 13 weeks apoptosi feature 52 weeks signi cockayne factor phenotype csbm /m animals csbm /m pups model tissue trichothiodystrophy parameter age-related nucleotide excision repair ageing endosteal hoeijmaker metabolism differentiation photoreceptor loss femur adipocyte mesenchymal csbm /m mouse bone mass endocortical volume
5 Most Recent Publications
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SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities
(Article)
Ju, L. Wing, J. Adler, T. Becker, J. Rozman, J. Klingenspor, M. Hanssen-de Wolf, J.E. Zimmer, A. Klopstock, T. Busch, D.H. Gailus-Durner, V. Fuchs, H. Taylor, M.E. Angelis, M.H. de Horst, G.T.J. van der Lehmann, A.R. Brandt, R.M.C. Slijepcevic, P. Horsch, M. Rathkolb, B. Rácz, I. Becker, M.L. Bijlsma, J.W.J. |
2013-03-19
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Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice
(Article)
Diderich, K. Nicolaije, C. Hoeijmakers, J.H.J. Leeuwen, J.P.T.M. van Priemel, M. Waarsing, J.H. Day, J.S. Brandt, R.M.C. Schilling, A.F. Botter, S.M. Weinans, H.H. Horst, G.T.J. van der |
2012-08-01
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Age-related skeletal dynamics and decrease in bone strength in DNA repair deficient male trichothiodystrophy mice
(Article)
Nicolaije, C. Diderich, K. Horst, G.T.J. van der Hoeijmakers, J.H.J. Leeuwen, J.P.T.M. van Botter, S.M. Priemel, M. Waarsing, J.H. Day, J.S. Brandt, R.M.C. Schilling, A.F. Weinans, H.H. Eerden, B.C.J. van der |
2012-04-10
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Retinal degeneration and ionizing radiation hypersensitivity in a mouse model for cockayne syndrome
(Article)
Gorgels, T.G.M.F. Pluijm, I. van der Hoeijmakers, J.H.J. Horst, G.T.J. van der Brandt, R.M.C. Garinis, G.A. Steeg, H. van Aardweg, G.J. van den Jansen, G. Ruijter, J.M. Bergen, A.A.B Norren, D. van |
2007-02-01
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Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome.
(Article)
Pluijm, I. van der Garinis, G.A. Niedernhofer, L.J. Velasco, S. Friedberg, E.C. Tanaka, K. Steeg, H. van Hoeijmakers, J.H.J. Horst, G.T.J. van der Brandt, R.M.C. Gorgels, T.G.M.F. Wijnhoven, S.W.P. Diderich, K. Wit, J. de Mitchell, J.R. Oostrom, C.T.M. van Beems, R.B. |
2006-12-12
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