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sunitinib hypertension receptor endothelin proteinuria excretion macitentan kidney effect change oxidative stress sunitinib-induced tempol erasmus mc 8 days toxicity level administration figure sunitinib-induced hypertension protein sunitinib administration study endothelin system patient abnormality creatinine injury vehicle sunitinib withdrawal serum control inhibitor system kinase preeclampsia inhibition blockade stress tyrosine erasmu oxidative section treatment development control rats histological abnormalities eta receptor blockade glomeruli decrease response epithelial serum creatinine angiogenesi weight hypertensive disease podocyte foot processes van den meiracker kapper table 9- week – podocyte pressure downloaded experiment increase library factor urine light fication baseline kidney sections kidney disease ͻ0.05 angiogenesis inhibition dysfunction expression coadministration
1 Most Recent Publications
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The vascular endothelial growth factor receptor inhibitor sunitinib causes a preeclampsia-like syndrome with activation of the endothelin system
(Article)
Kappers, M.H.W. Smedts, F. Horn, T. Esch, J.H.M. van Sleijfer, S. Leijten, F.P.J. Wesseling, S. Strevens, H. Danser, A.H.J. Meiracker, A.H. van den |
2011-08-01
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