Wassenaar, M.J.E.

patient fracture acromegaly study disease prevalence control spine journal follow-up bone mineral density endocrinology disease control duration women european mineral signi acromegalic patients baseline research gender gonadal status bone turnover treatment density gonadal level factor osteoporosis analysis effect acromegalic regression analysis value z-score hypogonadism growth roelfsema f concentration signi ficantly change disease activity 7 years hormone ficant deformity serum metabolism european journal gonadal function acromegaly patients romijn ja fracture risk reference activity group 14 years turnover diagnosis hypopituitarism center function acromegaly european journal igf 1 concentrations table presence www.eje-online.org body mass index 2 years status non-vertebral fractures population sms analogs measurement replacement 1 year bone formation growth hormone remission