Beukel-Bakker, E.M. van den

airway patient study children treatment group dornase alfa fibrosis cf patients dornase disease rhdnase asthma respir fef 75 deposition function chapter fev 1 eur respir j lung function difference aerosol lung disease nebulizer symptom trial spirometry inhalation cf lung disease airways group change airway deposition effect measurement analysis sputum dnase particle pediatr pulmonol cough inhaled pediatr obstruction exacerbation adherence 4 weeks value result placebo nitric oxide lung clearance index z-score clearance improvement tidden device number baseline figure airways obstruction table therapy randomized efficacy airways deposition score parameter delivery control mucus infant fibrosis lung disease airway obstruction stocks j feno group saturation maintenance treatment increase volume