Lenhard, B.

sox 2 locus region igk locus chd 7 pre-b figure interaction pre-b cells 1-cre expression transcription recombination enhancer control segment syndrome analysis vk gene segments vh 81x ficient pro-b factor element immunity protein usage chromatin 220+cd table number germline development binding ctcf-de rearrangement absence igk enhancer interactions b cell development germline transcription knockdown vk region b cells level sox 2 peaks fraction charge syndrome vk usage mouse allele sequence sequencing 3 c-seq experiments -/- stage intracellular mutation experiment c-seq chain target nature ctcf occupancy charge chd 7 peaks pre-b cell stage speci proliferation sis element vh segments october genotype cause vk genes differentiation immunoglobulin deletion immunoprecipitation regulation ª2011