Gog, J.R.

epidemic influenza model infection dynamic population hla-b number epitope founder period advantage fixation hla-b 27-positive hosts cytotoxic t lymphocyte season system fi xation hla-b 27 strain mutant probability mutation effect fi ve founders population level summer winter immunity level proportion ctl epitope invasion study 27-positive table result winter epidemic distribution grenfell xation chain fi rst summer structure response epidemic seasons mechanism ctl epitopes hla-b 27-positive people population level impact ctl responses autumn bottleneck 8 months 100 ͉ influenza dynamics bottleneck spread virol nucleoprotein drift explanation parameter value cytotoxic assumption spicer lymphocyte rimmelzwaan biology oxford osterhau paper nucleoprotein gene phase virus persistence future science target offer