Grenfell, B.T.

influenza virus model infection population dynamic influenza virus number compartment tropism tract tissue pathogenicity epidemic strain immunity tissue tropism transmission influenza virus infection parameter level influenza viruses receptor probability infectivity within-host infectivity rate study affinity result fitness ıve population infection dynamics epithelial cells response epithelial binding hla-b value population level clearance vaccine epitope science sialic acids period disease function distribution heterogeneitie region excretion cytotoxic pandemic cytotoxic t cells difference acid differences founder antigenic pattern type i interferon outbreak particle infectivity rates virus pathogenicity equine sialic advantage within-host models tracheo-bronchial compartment between-host linkage fixation receptor binding affinity hla-b 27-positive hosts cytotoxic t lymphocyte estimate table virus infection airway