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cancer breast rhamm brca 1 aurka figure mutation depletion polarization carrier department centrosome expression acini brca 1 depletion breast cancer risk microtubule university epithelial breast cancer result mcf 10a cells tpx 2 differentiation 703-rhamm control tumor study center genetic carcinogenesi protein research activity brca 1 function epithelial apicobasal polarization image institute culture centre function experiment analysis biology luminal proteasome inhibition epithelial cells rhamm abundance assay apicobasal representative bright-field images aurka activity hospital mcf 10a pt 703-rhamm level volume november assembly medicine inhibition factor kinase model america growth abundance antibody interaction panel issue state breast carcinogenesis 1-rhamm www.plosbiology.org shrna oncology structure value polarity
