Beddington, R.

gata 6 embryo expression heart blastocyst endoderm development heart tube cell mass es cells factor transcription staining tissue wild-type gal staining mouse parietal endoderm cells extraembryonic defect gata 6 gene 6-/- chimeric embryos gata 4 chimeric analysis formation clone differentiation heterozygote mesoderm expression pattern protein 5.5 dpc genes dev 5.5 antibody membrane activity grosveld absence gata 6 expression heart formation extraembryonic tissues 5.5 dpc embryos galactosidase activity wild-type es cells 7.5 dpc gata 6 protein probe 6+/- culture implantation parietal intercrosse haematopoietic system robertson wild-type blastocysts gastrulation outgrowth pattern galactosidase gata 6-/- cells reichert stage myocardium gata 6 rna orkin gata 6 locus gata 6 cdna heart tube formation parietal endoderm mouse embryo 9.5 inactivation 4.5 dpc heterozygote intercrosses erythroid embo j lethality