Nilsson, M.

'Planetary boundaries'-exploring the challenges for global environmental governance (Article)

2012-01-01T00:00:00Z

A range of studies from Earth system scientists argue that human activities drive multiple, interacting effects that cascade through the Earth system. Recent contributions state and quantify nine, interacting 'planetary boundaries' with possible threshold effects. This article provides an overview of the global governance challenges that follow from this notion of multiple, interacting and possibly non-linear 'planetary boundaries'. Here we discuss four interrelated global environmental governance challenges, as well as some possible ways to address them. The four identified challenges are related to, first, the interplay between Earth system science and global policies, and the implications of differences in risk perceptions in defining these boundaries; second, the capacity of international institutions to deal with individual 'planetary boundaries', as well as interactions between them; third, the role of international organizations in dealing with 'planetary boundaries' interactions; and fourth, the role of global governance in framing social-ecological innovations.

Tipping toward sustainability: Emerging pathways of transformation (Article)

2011-11-01T00:00:00Z

This article explores the links between agency, institutions, and innovation in navigating shifts and large-scale transformations toward global sustainability. Our central question is whether social and technical innovations can reverse the trends that are challenging critical thresholds and creating tipping points in the earth system, and if not, what conditions are necessary to escape the current lock-in. Large-scale transformations in information technology, nano- and biotechnology, and new energy systems have the potential to significantly improve our lives; but if, in framing them, our globalized society fails to consider the capacity of the biosphere, there is a risk that unsustainable development pathways may be reinforced. Current institutional arrangements, including the lack of incentives for the private sector to innovate for sustainability, and the lags inherent in the path dependent nature of innovation, contribute to lock-in, as does our incapacity to easily grasp the interactions implicit in complex problems, referred to here as the ingenuity gap. Nonetheless, promising social and technical innovations with potential to change unsustainable trajectories need to be nurtured and connected to broad institutional resources and responses. In parallel, institutional entrepreneurs can work to reduce the resilience of dominant institutional systems and position viable shadow alternatives and niche regimes.

Genetic determinants of serum testosterone concentrations in men (Article)

2011-10-01T00:00:00Z

Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts and followed up the genome-wide significant findings in one in silico (n = 871) and two de novo replication cohorts (n = 4,620) to identify genetic loci significantly associated with serum testosterone concentration in men. All these loci were also associated with low serum testosterone concentration defined as <300 ng/dl. Two single-nucleotide polymorphisms at the sex hormone-binding globulin (SHBG) locus (17p13-p12) were identified as independently associated with serum testosterone concentration (rs12150660, p = 1.2×10-41and rs6258, p = 2.3×10-22). Subjects with ≥3 risk alleles of these variants had 6.5-fold higher risk of having low serum testosterone than subjects with no risk allele. The rs5934505 polymorphism near FAM9B on the X chromosome was also associated with testosterone concentrations (p = 5.6×10-16). The rs6258 polymorphism in exon 4 of SHBG affected SHBG's affinity for binding testosterone and the measured free testosterone fraction (p<0.01). Genetic variants in the SHBG locus and on the X chromosome are associated with a substantial variation in testosterone concentrations and increased risk of low testosterone. rs6258 is the first reported SHBG polymorphism, which affects testosterone binding to SHBG and the free testosterone fraction and could therefore influence the calculation of free testosterone using law-of-mass-action equation.