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scopus: 21933445000

Elens, L.

(Laure Elens)


cyp 3a cyp 3a activity patient cyp 3a allele allele simvastatin study activity genotype effect cyp 3a carriers carrier midazolam cancer intron cyp 3a metabolizers reference oh-mdz pharmacokinetic erythromycin difference metabolism status 1´‑ allelic metabolizer model erythromycin breath test result therapy statin cyp 3a genotypes level association clearance response cholesterol polymorphism cyp 3a genotype group concentration 1´‑ oh-mdz reduction simvastatin therapy van schaik rh cyp 3a snp pharmacol cytochrome cancer patients table article measurement mdzdadj bolus administration <0.001 parameter pharmacogenomic figure expression ldlc levels influence population probe variant t-variant administration future cluster research analysis point t-variant allele carriers science cyp 3a expressers mg /l liver breath hepatic pharmacogenetic lipid




2 Most Recent Publications

CYP3A4 intron 6 C>T SNP (CYP3A4*22) encodes lower CYP3A4 activity in cancer patients, as measured with probes midazolam and erythromycin (Article)
Elens, L. Nieuweboer, A.J.M. Clarke, S.J. Charles, K.A. Graan, A-J.M. de Haufroid, V. Mathijssen, R.H.J. Schaik, R.H.N. van
2013-01-01
Novel CYP3A4 intron 6 single nucleotide polymorphism is associated with simvastatin-mediated cholesterol reduction in the Rotterdam Study (Article)
Elens, L. Becker, M.L. Haufroid, V. Hofman, A. Visser, L.E. Uitterlinden, A.G. Stricker, B.H.Ch. Schaik, R.H.N. van
2011-12-01