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cyp 3a cyp 3a activity patient cyp 3a allele allele simvastatin study activity genotype effect cyp 3a carriers carrier midazolam cancer intron cyp 3a metabolizers reference oh-mdz pharmacokinetic erythromycin difference metabolism status 1´‑ allelic metabolizer model erythromycin breath test result therapy statin cyp 3a genotypes level association clearance response cholesterol polymorphism cyp 3a genotype group concentration 1´‑ oh-mdz reduction simvastatin therapy van schaik rh cyp 3a snp pharmacol cytochrome cancer patients table article measurement mdzdadj bolus administration <0.001 parameter pharmacogenomic figure expression ldlc levels influence population probe variant t-variant administration future cluster research analysis point t-variant allele carriers science cyp 3a expressers mg /l liver breath hepatic pharmacogenetic lipid
2 Most Recent Publications
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CYP3A4 intron 6 C>T SNP (CYP3A4*22) encodes lower CYP3A4 activity in cancer patients, as measured with probes midazolam and erythromycin
(Article)
Elens, L. Nieuweboer, A.J.M. Clarke, S.J. Charles, K.A. Graan, A-J.M. de Haufroid, V. Mathijssen, R.H.J. Schaik, R.H.N. van |
2013-01-01
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Novel CYP3A4 intron 6 single nucleotide polymorphism is associated with simvastatin-mediated cholesterol reduction in the Rotterdam Study
(Article)
Elens, L. Becker, M.L. Haufroid, V. Hofman, A. Visser, L.E. Uitterlinden, A.G. Stricker, B.H.Ch. Schaik, R.H.N. van |
2011-12-01
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