Serneels, S.

mutation disease polymorphism alzheimer patient study amyloid association analysis plaque allele presenilin region control family psen 1 genotype promoter intron sequence dementia onset table protein ps -2 vessel brain linkage linkage disequilibrium genet frequency flemish van broeckhoven c intronic early-onset figure deposit sample chromosome presenile plaque cores presenile ad section intron 8 polymorphism pathology ad /fl broeckhoven autosomal presenile ad cases 182ex duijn acta neuropathol antibody variation neurol amyloid deposits expression amyloid angiopathy ad /fl brains onset age presenilin 1 gene early-onset ad sequencing genetic restriction hchwa-d van duijn cm 2823 i /d psen 1 mutations population-based cruts m promoter polymorphism sscp analysis alzheimer disease ad patients disequilibrium van harskamp f ps -2 mutation –48 48 ct