Hutton, M.

mutation family disease ps -2 onset alzheimer patient analysis presenile study polymorphism presenile ad chromosome autosomal presenile ad cases 182ex allele onset age sequence table presenilin dementia missense ps -2 mutation genotype missense mutations protein apolipoprotein linkage analysis studies linkage ps -2 cdna restriction onset ages frequency genetic sscp analysis cycle 118 control individuals broeckhoven intronic restriction enzyme digestion ps -2 mutations family history product department control pattern chromosome 1 sample pcr amplification genet nature sequencing enzyme amplification 79val primers pcr cycle sequencing region individual presenile ad families 5- non-coding region 10 coding exons ala 79val mutation primer ad cases acids research apolipoprotein e sscp patterns early-onset alzheimer mutation data mutation analysis allele frequencies alzheimer disease coding digestion glu 318gly ad genes ad families mutation frequency