Sherwin, C.M.T.

model dataset postnatal age clearance dosing neonate covariate pharmacokinetic model postnatal amikacin value concentration pharmacokinetic birthweight ibuprofen maturation postmenstrual age patient filtration rate ctrough model-building datasets regimen function dosing regimens amikacin clearance term neonates preterm co-administration model-based dosing regimen analysis population study distribution parameter figure target model-building table evaluation range target ctrough values filtration information postmenstrual ctrough values pharmacokinet point method bodyweight estimate paediatric model-based right 100.0 dosing guidelines 1.0 1.5–3 mg /l infusion postnatal maturation dosing regimen allometric function 10.0 children sample birth interval pediatr allegaert aminoglycoside result covariate analysis antenatal maturation parameter estimates variability pharmacol population-predicted concentration-time profiles dosing interval patent ductus arteriosus guideline