Labelle-Dumais, C.

col 4a mutation col 4a mutations variant control collagen protein american journal hemorrhage domain intracellular heterotrimer individual identi col 4a variants col 4a heterotrimers figure stress genetic col 4a proteins secretion intracellular col 4a disease identi fied american intracellular accumulation extracellular upr activation patient membrane col 4a variant nc 1 domain basement activation cells transfected intracerebral ratio stroke p.pro consequence transfected journal cause january retention identi fication intracerebral hemorrhage cohort mutation col 4a table coding result type iv collagens variants identi fied level nonsynonymou col 4a secretion protein response history triple-helix-forming domain intracellular ratio expression basement membranes accumulation assay factor signi analysis mouse gould neurology porencephaly formation sequence ht 1080 cells polymorphism effect collagen iv phenotype penetrant cerebrovascular diseases