Cook, P.R.

enhancer transcription chromatin factory insulator promoter locus factor silencer model expression transcription factors element genet transcriptional interaction function genome gene expression cook pr target chromosome organization polymerase protein example β- globin locus transcription factories epigenetic looping kolovo polycomb gene regulation transcription units grosveld f domain activation globin science unit 1 acts regulation region agrna palstra rj fraser p binding unit 1 dekker j mirna factory b units 2 boundary nature target promoters groudine m grosveld chromatin fibre histone cohesin b-globin receptor conformation drosophila knoch rnapii differentiation cremer chromatin domains nucleus noncoding modification mechanism cell types figure chromatin hub enhancer-promoter histone h 3 sequence splinter e action