Rein, N. van

isotretinoin isotretinoin users contraceptive group reference group compliance method reference prescription patient study product anti-acne medication population contraception pregnancy cpa /ee women medication prescriber proportion database anti-acne period 15–49 years drug safety dutch signi ficantly treatment netherland specialist wiley prevalence pregnancy prevention programme innovator contraceptives reference group pharmacoepidemiology programme 30 days pharmacy copyright signi prevention pharmacist information safety adherence 10.1002/ number 10.1002/ pds 2- year periods isotretinoin prescription age group performance contraception use isotretinoin use anti-acne treatment 15–49 guideline table innovator product vs isotretinoin users group ficantly measure isotretinoin user group fi rst prescriber 49 years therapy 10.1002/ pds h drug utilisation study crijn teratogenicity statistic barrier speci requirement innovator product exposure identi teratogenic