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leukemia expression resistance lymphoblastic leukemia drug resistance apoptosi patient childhood lymphoblastic protein caspase children blood procaspase study treatment pieters r opal 1 expression cancer den boer ml level sample group apoptotic outcome activation leukemic pieter b-lineage prednisolone chapter vincristine caspase -3 activation probe leukemic cells l-asparaginase figure janka-schaub ge veerman ajp response t-lineage death analysis table sensitivity subtype van wering pathway prognosis relation daunorubicin agent apoptotic parameters probe sets tel-aml therapy value defect mitochondrial parp inactivation leukemia cells factor protocol gene expression number myeloid leukemia coall j biol chem relling mv gene-expression netherland pui ch cell lines prognostic treatment outcome survival drug-induced drug-induced apoptosis opal 1 result
6 Most Recent Publications
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Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells
(Article)
Hulleman, E. Kazemier, K.M. Holleman, A. VanderWeele, D.J. Rudin, C.M. Broekhuis, M.J.C. Evans, W.E. Pieters, R. Boer, M.L.D. |
2009-02-26
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Novel genomic determinants of apoptotic defects in acute lymphoblastic leukemia
(Doctoral Thesis)
Holleman, A. |
2006-01-13
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Asparagine synthetase expression is linked with L-asparaginase resistance in TEL-AML1-negative but not TEL-AML1-positive pediatric acute lymphoblastic leukemia
(Article)
Stams, W.A. Boer, M.L. den Holleman, A. Appel, I.M. Beverloo, H.B. Wering, E.R. van Janka-Schaub, G.E. Evans, W.E. Pieters, R. |
2005-01-01
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Decreased PARP and procaspase-2 protein levels are associated with cellular drug resistance in childhood acute lymphoblastic leukemia
(Article)
Holleman, A. Boer, M.L. den Kazemier, K.M. Beverloo, H.B. Bergh, A.R.M. von Janka-Schaub, G.E. Pieters, R. |
2005-01-01
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Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment
(Article)
Holleman, A. Cheng, C. Veerman, A.J. Kazemier, K.M. Pei, D. Pui, C.H. Evans, W.E. Relling, M.V. Pieters, R. Janka-Schaub, G.E. Cheok, M.H. Boer, M.L. den Yang, W. |
2004-01-01
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Resistance to different classes of drugs is associated with impaired apoptosis in childhood acute lymphoblastic leukemia
(Article)
Holleman, A. Boer, M.L. den Kazemier, K.M. Janka-Schaub, G.E. Pieters, R. |
2003-01-01
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