Appel, I.M.

l-asparaginase children level patient lymphoblastic leukemia study leukemia treatment asparaginase asparagine group coagulation factor lymphoblastic protein leukemic cells peg-asparaginase childhood blood effect response leukemic figure activity expression serum stroke induction therapy parameter change value resistance glutamine paronal result thrombin generation thrombosis intracellular table depletion dexamethasone infusion l-asp diagnosis outcome sample chapter protocol window age groups den boer ml coagulation parameters peg-asp difference range synthetase administration thrombin preparation signi tel-aml responder pieters r pieter pharmacodynamic lasparaginase generation prothrombotic coagulation factors pharmacokinetic fibrinolysi system plasma reference coli l-asparaginase antithrombin aspartic acid synthesis exposure perinatal stroke