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vector therapy expression blood patient gene therapy insertion integration analysis development study t-cell trial publication number animal level t-cell development hematopoietic figure factor il 2rg 5- aed lmo 2 cancer leukemia recovery 34+ marrow cd 34+ cells murine oncogene table administration tumor insertional transduced effect assay sample clonal protein gene therapy trials virus transplantation insertional mutagenesis result phase receptor scid-x gene expression progenitor kgf-treated animals distribution mutagenesi clonal dominance control thymic treatment hum gene t cells genome phase i study experiment thymopoiesi article t-all group clone transfer category transcription adenoviral model spleen thymocyte research science phase i trial stage
10 Most Recent Publications
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Overestimation of hematopoietic stem cell frequencies in human liver grafts
(Article)
Hall, S.R. Pedroza-Gonzalez, A. Pan, Q. Tilanus, H.W. Jonge, J. de Wagemaker, G. Laan, L.J.W. van der |
2013-04-10
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In Vivo Expansion of Co-Transplanted T Cells Impacts on Tumor Re-Initiating Activity of Human Acute Myeloid Leukemia in NSG Mice
(Article)
Bonin, M. von Wermke, M. Cosgun, K.N. Thiede, C. Bornhauser, M. Wagemaker, G. Waskow, C. |
2013-04-09
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5-androstene-3β,17β-diol promotes recovery of immature hematopoietic cells following myelosuppressive radiation and synergizes with thrombopoietin
(Article)
Aerts Kaya, F.S.F. Visser, T.P. Arshad, S.H. Frincke, J. Stickney, D.R. Reading, C.L. Wagemaker, G. |
2012-11-01
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Keratinocyte Growth Factor and Stem Cell Factor to Improve Thymopoiesis after Autologous CD34
+ Cell Transplantation in Rhesus Macaques
(Article)
Wils, E-J. Aerts Kaya, F.S.F. Rombouts, E.J. Mourik, I. van Rijken-Schelen, A. Visser, T.P. Braakman, E. Wagemaker, G. Cornelissen, J.J. |
2012-01-01
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New insights and unresolved issues regarding insertional mutagenesis in X-linked SCID gene therapy
(Article)
Pike-Overzet, K. Burg, M. van der Wagemaker, G. Dongen, J.J.M. van Staal, F.J.T. |
2007-11-01
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An inventory of shedding data from clinical gene therapy trials
(Article)
Schenk-Braat, E.A.M. Mierlo, M.K.B. van Wagemaker, G. Bangma, C.H. Kaptein, L.C.M. |
2007-10-01
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Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo
(Article)
Schwarzwaelder, K. Howe, S.J. Parsley, K.L. Gilmour, K.C. Sinclair, J. Bayford, J. Peraj, R. Pike-Overzet, K. Staal, F.J.T. Ridder, D. de Kinnon, C. Abel, U. Schmidt, M. Wagemaker, G. Gaspar, H.B. Thrasher, A.J. Kalle, C. von Brugman, M.H. Deichmann, A. Glimm, H. Prinz, C. Wissler, M. King, D.J.S. Zhang, F. |
2007-08-01
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Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy
(Article)
Deichmann, A. Hacein-Bey-Abina, S. Fischer, N. Schwarzwaelder, K. Siegler, M.-L. Ridder, D. de Pike-Overzet, K. Howe, S.J. Thrasher, A.J. Wagemaker, G. Abel, U. Staal, F.J.T. Schmidt, M. Delabesse, E. Villeval, J.-L. Aronow, B. Hue, C. Prinz, C. Wissler, M. Klanke, C. Weissenbach, J. Alexander, I. Kalle, C. von Garrigue, A. Cavazzana-Calvo, M. Brugman, M.H. Hu, J. Glimm, H. Gyapay, G. Prum, B. Fraser, C.C. |
2007-08-01
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Ectopic retroviral expression of LMO2, but not IL2Rγ, blocks human T-cell development from CD34+ cells: Implications for leukemogenesis in gene therapy
(Article)
Pike-Overzet, K. Ridder, D. de Dongen, J.J.M. van Staal, F.J.T. Weerkamp, F. Baert, M.R. Verstegen, M.M.A. Brugman, M.H. Howe, S.J. Reinders, M.J.T. Thrasher, A.J. Wagemaker, G. |
2007-04-01
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Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways
(Article)
Kustikova, O.S. Geiger, H. Cornils, K. Nattamai, K.J. Modlich, U. Wagemaker, G. Goodell, M.A. Fehse, B. Baum, C. Li, Z. Brugman, M.H. Chambers, S.M. Shaw, C.A. Pike-Overzet, K. Ridder, D. de Staal, F.J.T. Keudell, G. von |
2007-03-01
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