Sissmann, J.

van den meiracker effect hypertension receptor antagonist group irbesartan renin plasma treatment study value angiotensin 1 receptor antagonist placebo ang ii 100- mg dose 100- treatment groups article change patient 24- hour hemodynamic 25- meiracker 25- mg dose 100- mg doses blood concentration diastolic bp values 1 receptor blockade period losartan 24 hours 1- mg dose ang i antihypertensive effect response diastolic antihypertensive 24- baseline values window baseline heart systolic blockade aldosterone administration blood pressure heart rate order article angiotensin ii table measurement 5 ml blood plasma renin concentration randomization renin-angiotensin system method increase study day 100 mg j hypertens sodium inhibitor system pressure circle placebo group plasma norepinephrine sodium excretion timmermans pbmwm bp-lowering effect renin-angiotensin renin concentration result compound single-blind