Tümkaya, T.

rearrangement region probe chain b-cell segment analysis leukemia immunoglobulin allele restriction expression figure patient malignancy polymorphism blot analysis isotype amplification light sequence detection receptor table locus digest study b-cell malignancies fragment antigen recombination chapter igl amplification polymorphism iga gene rearrangements ecori protein dongen result dna probes deletion allelic exclusion iglc 3 probe clonal lambda enzyme myeloma allelic membrane exclusion process blood sample frequency restriction enzymes germline identification junctional leder p j gene segments differentiation combination reanangement gene rearrangements restriction fragments lymphoma primers molecule nucleotide igl gene rearrangements j-c 2 region receptor editing clonality studies digestion b-cell differentiation lymphoblastic leukemia lymphoblastic hybridization pattern rotterdam gennline