Nieuwenhuizen, I.M.

mouse protein brain level x syndrome instability neuron fxr 1p study spine knockout syndrome inclusion length region fmr 1 gene wild-type fxr 1 þ expansion response genet expression muscle premutation transmission mglur analysis wild-type mice allele phenotype retardation model genetic fmr 1 mrna fxr 2p dendritic difference mutation tissue protrusion antibody retardation protein intranuclear inclusions result number prepulse mouse model prepulse inhibition hippocampal afq 056 disease inhibition fxr 1 ko fmr 1 promoter oostra morphology human presence figure contraction function intranuclear expanded-repeat mglur 5 expression absence section carrier patient hagerman warren 3 region hippocampu dendritic spine length fmr 1 ko wt mice littermate signi cortex mechanism