Cortes, L.M.P.

patient study population ms patients 0.001 type 1 diabetes glaucoma heritability sclerosis thickness variance 48 ms patients disease rnfl thickness erasmus univ rotterdam ophthalmol thyroid disease parameter netherland disc area rotterdam diabetes family control genet thyroid allele estimate subject pressure table heritability estimates arch ophthalmol variance component analyses open-angle glaucoma distribution gender ratio effect measurement analysis hla-drb coefficient pedigree cup-to-disc ratio signi ficantly curvature erasmu cup shape measure neuroretinal rim area proportion kinship genealogical ancestor onset phenotypic variance relative signi information regression length component factor coef ficient symptom onset prevalence hla-drb 1*15 allele rim area determinant marker equivalent analyses ficient open-angle hemi field additive heritability estimate individual research diagnosis