Sklenar, I.

sam 486a patient study cancer 5- fu 5- fu /lv infusion treatment phase level cycle metastatic colorectal cancer grade toxicity 125 mg /m combination colorectal dose level concentration fluorouracil analysis sample response pharmacokinetic regimen colorectal cancer table inhibitor metastatic polyamine plasma clearance fatigue 2 weeks event disease blood phase i studies agent 22- h infusion 3 days auc 0- value leucovorin schedule decarboxylase auc 0-t gramont profile administration limit novel tumor concentration-time oncology single-agent sam 486a sam 486a infusion fatigue grade 3 cohort regression 5- fu treatment regression analysis time point grade 1 fatigue 12 cycles function phase i study chemotherapy criteria peak area ratios pk analysis terminal disposition phase plasma concentration-time curve laboratory studies phase i 5 days method single-agent s-adenosylmethionine decarboxylase inhibitor 100 mg /m