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Choi, L.
( L. Choi)
sccro patient neddylation cand 1 study sam 486 cancer level cullin sam 486a infusion treatment ubc 12 grade protein reaction cullin neddylation lysate phase mmi 270b plasma binding cul 1-roc effect food intake administration concentration dose level analysis toxicity inhibitor pharmacokinetic polyamine cycle ubc 12ϳnedd 1-roc 5- fu assay dose levels 5- fu /lv sample sccro ϫ/ϫ mice thioester panel 12ϳnedd result interaction neddylated blood pulldown complex 2 weeks addition erasmus mc 270 mg /m limit intake metastatic colorectal cancer neddylation e 3 peak plasma levels fasted disease infusion time cand 1. phase i roc 1 release decarboxylase bottom panel 4 ° c ubc 12ϳnedd thioester combination tumor 125 mg /m cand 1 release nedd 8 response presence unneddylated component
4 Most Recent Publications
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SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation
(Article)
Kim, A.Y. Bommeljé, C.C. Ramanathan, Y. Singh, B. Lee, B.E. Yonekawa, Y. Choi, L. Morris, L.G. Huang, G. Kaufman, A. Ryan, R.J.H. Hao, B. |
2008-11-28
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Phase I and pharmacokinetic study of the polyamine synthesis inhibitor SAM486A in combination with 5-fluorouracil/leucovorin in metastatic colorectal cancer
(Article)
Zuylen, L. van Mueller, C. Choi, L. Bootle, D. Verweij, J. Ledermann, J.A. Bridgewater, J. Sparreboom, A. Eskens, F.A.L.M. Bruijn, P. de Sklenar, I. Planting, A.S.Th. |
2004-01-01
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Effect of food on the pharmacokinetics of oral MMI270B (CGS 27023A), a novel matrix metalloproteinase inhibitor
(Article)
Eskens, F.A.L.M. Levitt, N.C. Sparreboom, A. Choi, L. Mather, R. Verweij, J. Harris, A.L. |
2000-01-01
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Phase I and pharmacological study of weekly administration of the polyamine synthesis inhibitor SAM 486A (CGP 48 664) in patients with solid tumors. European Organization for Research and Treatment of Cancer Early Clinical Studies Group
(Article)
Eskens, F.A.L.M. Zuylen, C. van Capdeville, R. Greim, G.A. Wolff, I. Denis, L.J. Planting, A.S.Th. Muskiet, F.A. Wanders, J. Barbet, N.C. Hanauske, A.R. Choi, L. |
2000-01-01
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