Hollak, C.E.M.

gaucher patient gaucher patients disease plasma level therapy mip -1β gaucher disease range chitotriosidase mip -1β levels mip -1α plasma mip -1β spleen fraction control gaucher cells marrow bone complications van breemen bone marrow complication plasma levels / biochimica 5 years activity chemokine plasma mip -1α marker treatment ccl 18 macrophage plasma chitotriosidase enzyme subject analysis protein breemen hollak value gaucher spleen avascular necrosis biophysica chemical shift imaging serum biochimica gaucher cell markers j.m.f.g antibody section result enzyme replacement therapy method age 39 years myeloma storage sample bone crises control subjects study mip 1β 788–796 blood effect chemical resorption response c.e.m individual rank correlation test plasma mip -1β. rank /rankl system chitotriosidase wild-type individuals fracture chitotriosidase activity tissue gaucher cell burden splenectomized gaucher patients reduction