Vinks, A.A.

model infusion concentration pharmacokinetic antibiotic ceftazidime patient parameter antimicrobial agents study adaptation rate growth value growth rate adaptation result efficacy agent mouton pharmacodynamic antimicrobial clearance serum infection chemotherapy strain body clearance fibrosis aeruginosa effect bacteria mactam / mactams 4 x mic experiment animal pk-pd regimen / mactam antibiotics serum concentrations journal microbiology activity population curve simulation target concentration modeling dosing regimens interscience conference bacterium function program lactam two-population model rate constants /liter pharmacodynamic parameter agents chemother hill coefficient group relationship /?- lactam antibiotics target elimination number mattie human disease pk-pd model tissue dosing 0.1 pharmacokinetic model american ec 50 antibiotic concentrations aeruginosa strains fluid factor