Punt, C.J.

9- ac model pharmacokinetic lactone 9- ac lactone patient cancer sample time points sample concentration strategy point study prediction plasma correlation analysis jonge sparreboom camptothecin curve administration 9- aminocamptothecin drug administration regression verweij j coefficient phase phase i verweij correlation coefficients jonge mja limited-sampling aminocamptothecin value table exposure loos wj tumor time points kozielski aj pharmacokinetic parameters pharmacokinetic curves limited-sampling strategies stehlin js bivariate models validation topoisomerase irinotecan training sampling schedule carboxylate univariate sampling model tamura t nooter k parameter sample time point camptothecin analogs dosing treatment ng h /ml giovanella 72- hour infusion estimation hinz hr validation-data bivariate modeling plasma concentration-time curve university hospital rotterdam adult cancer patients potmesil concentration-time percent root mean-squared oncol stoter g rotterdam cancer institute nakashima h