Huizenga, N.A.T.M.

cortisol receptor concentration patient glucocorticoid n 363s carriers gr gene level carrier study resistance mutation cushing polymorphism sensitivity 22/23ek carriers subject syndrome binding control effect difference glucocorticoid resistance insulin endocrinol domain glucocorticoid receptor gene 22/23ek 0.25 mg dex analysis tumor cortisol resistance glucocorticoid receptor result disease serum suppression cortisol concentrations serum cortisol concentrations table 0.25 response number dexamethasone hormone individual group noncarrier blood metab 1 mg dex feedback chapter expression transcription variant ligand function library erasmus mc administration protein hormone binding domain dex concentrations cortisol suppression assay affinity factor cortisol levels figure plasma point change ligand affinity fasting baseline gr gene locus secretion codon baseline cortisol concentrations lambert