Steine, E.A.

methylation tumor dnmt 3b cancer dnmt 3a dna methylation expression methylated methyltransferase colon mouse promoter figure control region chapter analysis tissue histone development apcmin /+ mice target colon cancer genome study nature research tumorigenesi dnmt 3b expression sample pattern deletion hypomethylation tumor suppressor genes hypermethylation mucosa mutation genomic allele dnmt 1 dna methyltransferases model cytosine apcmin imprinting science 0.000 gene expression sequence protein result institute ectopic suppressor number chromatin change intestine jaenisch es cells domain transgene 0.001 tumor development colon epithelial cells wt tumors dnmt 3b induction dnmt 3b overexpression modification journal overexpression epithelial function control mice cancer cells cpg islands colon tumors genetic igf 2 level