Spil, W.E. van

radiographic knee oa association radiographic adipokine level subject cartilage osteoarthritis baseline progression grade adiponectin leptin study presistin plasma k &l grade resistin serum biomarker knee oa padiponectin metabolism presence pleptin van spil regression marker plasma adipokine levels cohort regression coef ficients incidence variable check / osteoarthritis synovial signi signi ficant associations plasma adiponectin levels center /or right knee early-stage knee oa biomarker levels 5 years type ii collagen body mass index ficant 2- year changes <0.001 rheum patient obesity early-stage spiiinp ficient n-terminal propeptide right gender adjustment signi ficant interaction arthritis 5- year follow-up flammatory interaction type iia procollagen type iii procollagen /unit plasma adipokines spiianp disease right knee fi ndings check subjects number uctx-ii scomp 1002 subjects follow-up coeff table