Sciuscio, D.

(Davide Sciuscio)

methylation glioblastoma model probe ﬁcation promoter value classi status patient dataset glioma methylated mgmt methylation classi ﬁcation prediction mgmt promoter methylation mgmt-stp sample survival probability mgmt methylation status -450k methylation status grade hm -450k tumor mgmt-stp 27 expression outcome cancer 1.0 0.0 0.8 mgmt-stp 27 model 0.6 0.4 0.2 mgmt promoter island analysis trial anaplastic region unmethylated alkylating agent therapy temozolomide neuropathol −glioma association platform proportion bene ﬁt cohort figure mgmt status anaplastic glioma hm -27k cpg island identi study location vb-glioma-iii p values ms-pseq regression grade ii van den response methylation-speci ﬁc pcr gene expression mgmt expression oncol m-gbm tcga-gbm information table therapy treatment correlation

1 Most Recent Publications

MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status (Article)
Bady, P. Sciuscio, D. Mcdonald, D.R. Lacombe, D. Stupp, R. Delorenzi, M. Hegi, M.E. Diserens, A.C. Bloch, J. Bent, M.J. van den Marosi, C. Dietrich, P-Y. Weller, M. Mariani, L. Heppner, F.L.

2012-10-01

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