Innocenti, F.

method database event protopathic bias signal leopard gamma poisson shrinker safety pharmacoepidemiol drug saf performance drug reactions estimate exposure ratio number health record control protopathic system detection prescription reference effect bayesian reaction drug saf 25 days fl agged speci ficity odds ratio drug-event evaluation leopard fi ltering risk estimates association eu-adr poisson schuemie drug safety signals curve shrinker gamma incidence rate ratio self-controlled case series patient combination pharmacovigilance william incidence case-based methods monitoring october volume eu-adr project schuemie mj lippincott agged cipro floxacin pharmacoepidemiol result drug-event pair wilkin lgps estimate model registry information hospital meta-analysi speci report drug safety monitoring italy european failure drug exposure infarction surveillance figure outcome