Tuna, B.G.

transglutaminase shear stress oscillatory transglutaminase activity oscillatory shear stress transglutaminase inhibition lesion expression inhibition tgm 2 activity region atherosclerosi shear stress macrophage content plaque muscle effect inhibitor signi ficantly shear stress region increase monocyte level control mice cd 68 artery oscillatory fl ow atherosclerotic signi model macrophage content control transglutaminase inhibitor staining protein muscle cells tissue transglutaminase muscle content lipid knockout quanti fication lesion size composition blood fl ow laminar shear stress grif fin m matlung shear stress area shear stress levels ficantly carotid transglutaminase 2 nitric oxide plaque composition tissue study oscillatory shear reduction monocytes /macrophages activation laminar lipid content 1.3 huvec endothelium result /macrophage perivascular cast muscle migration carotid arteries tgm 2 expression carotid artery fl ow-modifying cast tgm 2 mrna n ¼ 5 protein levels mouse