Zee, L. van der

polymorphism mutation association study ldlr gene signal variant population rotterdam study patient allele subject rotterdam genome-wide ldlr mutations frequency signi result ldlr mutation fh patients identi fied genome-wide association studies identi table carrier 1.00 analysis 464 fh patients associations dm oosterveer genome-wide signi ficantly signi ficant polymorphisms ficant 5945 subjects association signals 2.4 mb european journal genotype haplotype gwa study chromosome 19 genet 2157 subjects factor person cohort control fication genetic disease rs-ii 2189 patients european fh cohort flation sample identi fication fi ve persons allele frequencies rs 4804636 polymorphisms family relations ldlr locus population strati fication journal strati ldl cholesterol level genotype frequencies university risk factors screening program risk variants p-value fh phenotype hypercholesterolemia center department chromosome 0.13 lipoprotein netherland number