Huynh-Thu, V.

macrophage myelin cholesterol expression pathway metabolism lipid activation cholesterol efflux phenotype receptor mye-macrophage efflux analysis lipid metabolism response phagocytosi system sclerosis reference genes function protein liver result myelin phagocytosis myelin-phagocytosing lxrab-deficient mouse macrophages belgium microglia brain volume table downregulated study experiment production september myelin internalization figure www.plosone.org regulation intracellular 48 hours gene expression inflammation macrophage phenotype issue downregulated genes van rooijen n microarray member myelin activates lxrs reference van meurs m differentially lxr response genes rpmi 1640 medium factor t 0901317-treated macrophages j clin t 0901317 effect mouse method microarray analysis lxr /ppar university mediator intracellular cholesterol immunol overrepresented lesion upregulated process control netherland cycle secretion david capacity