Roks, G.

disease patient alzheimer polymorphism allele study control genotype association population frequency mutation rotterdam presenilin analysis early-onset onset dementia netherland duijn linkage linkage disequilibrium intron dutch apolipoprotein department creutzfeldt-jakob disease region −491 spanish onset ad rotterdam study early-onset ad iatrogenic cjd intronic genet late-onset neurology growth protein van broeckhoven university −491 polymorphism –48 apoe 4 allele neurol table hofman hormone growth hormone amyloid group sample population-based promoter atrophy apolipoprotein e gene presenilin –1 polymorphism creutzfeldt-jakob van duijn variation effect frontotemporal dementia incubation period context link dutch population evidence result family iatrogenic spanish population broeckhoven t allele flanders interuniversity institute tau gene population-based study disequilibrium presenilin –1 gene services task force psen 1