Valdivieso, F.

allele patient genotype population polymorphism dutch −491 spanish disease frequency control −491 polymorphism alzheimer linkage disequilibrium early-onset study region dutch population spanish population apolipoprotein e gene t allele apolipoprotein association spanish patients apoe *2 allele linkage disequilibrium early-onset ad signi analysis late-onset ficant apoe gene fi ndings signi ficant difference apoe 24 genotype evidence distribution dutch patients −491 aa genotype allele frequencies aa genotype apoe 33 genotype fi nding early-onset ad patients nding onset table genet difference 65–68 99 dutch neuroscience letter duijn apoe polymorphism early-onset form apoe genotype patients p promoter ad patients explanation netherland madrid alzheimer disease van broeckhoven van duijn population admixture p-value genotyping late-onset form genotype distribution tt genotype apoe *2 series maria j /t genotype allele distributions rotterdam −491 t allele