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expression b cells pre-b level development pre-b cells b cell development figure kinase protein gata 3 chain 2-gata receptor immunol surface thymocyte number cd 2-gata analysis gata 3 expression spleen dp cells stage b-cell tyrosine result activation -65 ficient control lymphoma selection t cell development e 41k lineage cd 2-gata mice btk mice slp -65 mouse function differentiation culture splenic factor tumor cd 19-hbtk mice btk-deficient rearrangement antibody transgene activity wild-type bruton gata -3 bone marrow tyrosine kinase presence fi broblasts pre-bcr c-myc hendrik proliferation background effect broblast immunity splenic b cells response leukemia imatinib mesylate transcription group flow cytometric analysis population fraction btk-deficient mice thymic thymu gata -3 expression
10 Most Recent Publications
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Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice
(Article)
Kil, L. Bruijn, M.J.W. de Loo, P.F. van Hendriks, R.W. Nimwegen, M. van Corneth, O.B.J. Hamburg, J.P. van Dingjan, G.M. Thaiss, F. Rimmelzwaan, G.F. Elewaut, D. Delsing, D. |
2012-04-19
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The neonatal Fc receptor is expressed by human retinal pigment epithelial cells and is downregulated by tumour necrosis factor-alpha
(Article)
Van Bilsen, K. Hagen, P.M. van Bastiaans, J. Meurs, J.C. van Missotten, T. Kuijpers, R.W.A.M. Hooijkaas, H. Dingjan, G.M. Baarsma, G.S. Dik, W.A. |
2011-06-01
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Pre-B-cell leukemias in Btk/Slp65-deficient mice arise independently of ongoing V(D)J recombination activity
(Article)
Ta, T.B.V. Haan, A.B. Bruijn, M.J.W. de Dingjan, G.M. Hendriks, R.W. |
2010-10-29
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Constitutive activation of Bruton's tyrosine kinase induces the formation of autoreactive IgM plasma cells
(Article)
Kersseboom, R. Kil, L. Flierman, R. Zee, M. van der Dingjan, G.M. Middendorp, S. Maas, A. Hendriks, R.W. |
2010-09-01
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Platelet-derived growth factor-BB: a stimulus for cytokine production by orbital fibroblasts in Graves' ophthalmopathy.
(Article)
Steensel, L. van Paridaens, D. Dingjan, G.M. Daele, P.L.A. van Hagen, P.M. van Kuijpers, R.W.A.M. Bosch, W.A. van den Drexhage, H.A. Hooijkaas, H. Dik, W.A. |
2010-01-01
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Imatinib mesylate and AMN107 inhibit PDGF-signaling in orbital fibroblasts: A potential treatment for Graves' ophthalmopathy
(Article)
Steensel, L. van Paridaens, D. Schrijver, B. Dingjan, G.M. Daele, P.L.A. van Hagen, P.M. van Bosch, W.A. van den Drexhage, H.A. Hooijkaas, H. Dik, W.A. |
2009-12-01
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Gene expression profiling in mice with enforced Gata3 expression reveals putative targets of Gata3 in double positive thymocytes
(Article)
Hamburg, J.P.v. Bruijn, M.J.W. de Ribeiro de Almeida, C. Dingjan, G.M. Hendriks, R.W. |
2009-10-01
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Cytokines in the colon of a patient with Behçet's disease
(Article)
Kappen, J.H. Dik, W.A. Dingjan, G.M. Daele, P.L.A. van Hooijkaas, H. Martin, M.P. Laar, J.A.M. van |
2009-08-27
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CTCF regulates cell cycle progression of αβ T cells in the thymus
(Article)
Heath, H. Ribeiro de Almeida, C. Hendriks, R.W. Galjart, N.J. Sleutels, F. Dingjan, G.M. Nobelen, S. van de Jonkers, I.H. Ling, K-W. Gribnau, J.H. Renkawitz, R. Grosveld, F.G. |
2008-11-05
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Cooperation of Gata3, c-Myc and Notch in malignant transformation of double positive thymocytes
(Article)
Hamburg, J.P. van Bruijn, M.J.W. de Dingjan, G.M. Beverloo, H.B. Diepstraten, H.J.A. Ling, K-W. Hendriks, R.W. |
2008-06-01
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