Dong, F.

g-csf receptor patient g-csf-r mutation region factor myeloid maturation granulocyte signal neutropenia response g-csf receptor leukemia growth domain cytoplasmic medium l-gm cells blood myeloid leukemia wild-type point mutation proliferation expression marrow murine wt g-csf-r colony-stimulating transfectant progenitor point clone marrow cells granulocyte colony-stimulating factor cytoplasmic domain product result analysis g-csf receptors copyright 1995 massachusetts culture baf 3 cells g-csf-containing medium transduction protein genomic dna pcr products fragment vector l-gm transfectants 32 d.wt cells digestion binding g-csf-r cdna table colony g-csf signal transduction myeloid progenitor cells l-gm /da cells interleukin growth signal transduction hematopoietic sscp analysis primers progenitor cells pcr product dc receptor nucleotide number sequence c-terminal cytoplasmic region patient 2 il -3 point mutations myeloid cell lines 1991. wild-type receptor table 2