Schelen, A.M.

mutation receptor g-csf patient g-csf-r factor idh 1 idh 2 mutations blood granulocyte wild-type activation analysis neutropenia myeloid domain granulocyte colony-stimulating factor ligand signal p 206h mutation response binding p 206h expression clone region marrow growth colony-stimulating marrow cells gcsfr extracellular domain concentration survival maturation progenitor medium idh 1 mutations leukemia l-gm cells extracellular effect stat activation myeloid leukemia signi ficantly g-csf-r cdna colony point mutation proliferation idh 2 ligand binding sites g-csf signal transduction murine sscp analysis npm 1mutant progenitor cells wild-type g-csf-r idh mutations differentiation g-csf treatment fragment figure result identi fied prognostic erasmus mc marrow progenitor cells protein scn patients myeloid cells cytoplasmic stat 5 genomic dna ligand binding karyotype intermediate-risk idh gene mutations stat 3 number signi