Spencer, J.H.

fragment endonuclease sequence oligonucleotide restriction strand enzyme product pyrimidine haeiii 13 dna bacteriophage number 4 x 174 13 rf dna pyrimidine oligonucleotides x 174 spencer nucleotide restriction fragments table base pairs electrophoresis research p-labeled fraction separation pyrimidine isostich analysis result column acids research haeiii 8 hydrolysis activity smith restriction endonuclease maps protein study position exonuclease digestion region method canada difference sinsheimer molecule comparison polyacrylamide hemophilu analysis preparation phage replicative restriction enzymes hydrolysate edge 11 length hemophilus influenzae tris-hcl snake venom phosphodiesterase 13 haeiii 8 fragments haeiii 8 gene ab region x 174 dna hemophilus aegyptius 10 hr figure determination mobility influenzae isostich nucleotide sequence solution enzyme activity strand separation cerny hhllo acrylamide specificity