Huhtaniemi, I.T.

receptor mutation hormone gonadotropin library erasmus mc endocrinol luteinizing protein function subunit level variant leydig luteinizing hormone fsh receptor lh receptor patient inactivating phenotype huhtaniemi study effect expression metab luteinizing hormone receptor domain missense activity testosterone cause testicular lh receptor gene action syndrome binding puberty subject erasmu development change production absence downloaded library follicle-stimulating gonadal model endocrinology follicle population signal extracellular structure extracellular domain activation factor november 2000 gonadotropin themmen transmembrane chorionic gonadotropin tumor leydig cells frailty mouse infertility secretion number ovary chorionic spermatogenesi polymorphism leydig cell hypoplasia 0.001 lh receptor function glycoprotein hormone receptors glycosylation deficiency fsh receptor gene glycoprotein