Smith, A.L.

strain tmp resistance resistance influenzae folh genes sequence folh 1 influenzae strains promoter folh 2 region level nucleotide influenzae r 1047 promoter region tmp susceptibility spain substitution r 1042 fragment trimethoprim alteration acid substitutions susceptibility tmp-resistant comparison restriction folh 3 dihydrofolate reductase haemophilus influenzae c-terminal part difference folh gene 64 g /ml domain agents chemother acid sequences plasmid dihydrofolate mechanism reductase influenzae r 1042 tmp resistance phenotype binding overproduction influenzae folh genes tmp-susceptible 128 g /ml folh 3 strains chemother phenotype hybrid agent styi-muni fragments haemophilu antimicrob ecori gene hybrids coli recombinants tmp-resistant h tmp mics styi-muni position analysis netherland exchange increase recombinant sequencing groot effect resistance phenotype 32 g /ml protein folh gene hybrids strains r 1047 pulsed-field gel electrophoresis spanish acid residues strains r 906