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    <title>Ende, J. van der</title>
    <link>http://repub.eur.nl/res/aut/6529/</link>
    <description>List of Publications</description>
    <language>en</language>
    <image>
      <url>http://repub.eur.nl/static-eur/img/logo.png</url>
      <title>RePub, Erasmus University Rotterdam</title>
      <link>http://repub.eur.nl</link>
    </image>
    <item>
      <title>A brief observational instrument for the assessment of infant home environment: Development and psychometric testing (Article)</title>
      <link>http://repub.eur.nl/res/pub/37736/</link>
      <pubDate>2012-09-01T00:00:00Z</pubDate>
      <description>The present paper reports on the development and the psychometric properties of a brief observational assessment of home environments for use in large-scale investigations with young infants. We generated observational items conceptually relevant for child development by two methods. First, we adapted the Infant Toddler Home Observation for Measurement of the Environment (IT-HOME) inventory for use in an exclusively observational context. Second, we added new observational items following a review of relevant literature and consulting professionals. The quality of the instrument was first evaluated in a pilot study (n = 926). In our study sample of 3406 families and their children (median age = 3.1 months, range = 1.6-6.0), exploratory factor analysis was used to identify latent constructs, Cronbach's alpha was used as a measure of internal consistency, and convergent validity was evaluated against family socio-demographic characteristics. Inter-observer agreement was investigated in a sub-sample of the respondents (n = 124). The results supported good psychometric properties of the instrument based on: (a) exploratory factor analysis yielding three meaningful latent constructs, (b) Cronbach's alphas ranging from α = 0.66 to α = 0.90, (c) inter-observer agreement ranging from r = 0.75 to r = 0.91, and (d) associations between the instrument and socio-demographic characteristics in the expected direction [e.g. Odds Ratio for low income = 15.24, 95% confidence interval (11.60, 20.01)] </description>
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      <title>Reliability and validity of the dutch version of the brief infant-toddler social and emotional assessment (BITSEA) (Article)</title>
      <link>http://repub.eur.nl/res/pub/37977/</link>
      <pubDate>2012-06-08T00:00:00Z</pubDate>
      <description>Background: The Brief Infant-Toddler Social and Emotional Assessment (BITSEA) is a relatively new and short (42-item) questionnaire that measures psychosocial problems in toddlers and consists of a Problem and a Competence scale. In this study the reliability and validity of the Dutch version of the BITSEA were examined for the whole group and for gender and ethnicity subgroups. Methods: Parents of 7140 two-year-old children were invited in the study, of which 3170 (44.4%) parents completed the BITSEA. For evaluation of the score distribution, the presence of floor/ceiling effects was determined. The internal consistency (Cronbach's alpha) was evaluated and in subsamples the test-retest, parent-childcare provider interrater reliability and concurrent validity with regard to the Child Behavioral Checklist (CBCL). Discriminative validity was evaluated by comparing scores of parents that worry and parents that do not worry about their child's development. Results: The BITSEA showed no floor or ceiling effects. Psychometric properties of the BITSEA Problem and Competence scale were respectively: Cronbach's alphas were 0.76 and 0.63. Test-retest correlations were 0.75 and 0.61. Interrater reliability correlations were 0.30 and 0.17. Concurrent validity was as hypothesised. The BITSEA was able to discriminate between parents that worry about their child and parents that do not worry. The psychometric properties of the BITSEA were comparable across gender and ethnic background. Conclusion: The results in this large-scale study of a diverse sample support the reliability and validity of the BITSEA Problem scale. The BITSEA Competence scale needs further study. The performance of the BITSEA appears to be similar in subgroups by gender and ethnic background. </description>
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      <title>The parallel development of ODD and CD symptoms from early childhood to adolescence (Article)</title>
      <link>http://repub.eur.nl/res/pub/25139/</link>
      <pubDate>2011-06-01T00:00:00Z</pubDate>
      <description>This study examined the developmental relations between symptoms of oppositional defiant disorder (ODD) and conduct disorder (CD) from early childhood to adolescence. Specifically we tested, according to parent-reported problems, whether symptoms of ODD precede the development of CD symptoms, whether ODD and CD symptoms are reciprocally associated across time, or whether ODD and CD symptoms develop parallel to each other across time. Participants were a community-based sample (at time 1: N = 485, 48% boys) assessed biannually five times from age 4 to 6 until age 12-14. The findings suggested that, with control for stability effects, baseline SES, and symptoms of attention deficit hyperactivity disorder, ODD and CD symptoms develop parallel to each other. No gender differences were obtained. We conclude that without the initial presence of CD symptoms, ODD symptoms are not developmental precursors to CD symptoms. </description>
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      <title>Maternal thyroid function during pregnancy and behavioral problems in the offspring: The generation R study (Article)</title>
      <link>http://repub.eur.nl/res/pub/26472/</link>
      <pubDate>2011-05-01T00:00:00Z</pubDate>
      <description>Maternal thyroid function during pregnancy is implicated in the neurodevelopment of the offspring, yet little is known about the effect of maternal thyroid parameters on the behavior of children. We investigated the association of maternal thyroid function during the first half of pregnancy with parent-reported problem behavior of the offspring up to age of 3 y. In the Generation R study, a population-based cohort of 3736 children and their mothers, data on maternal thyroid function and child's behavior were examined. The degree of internalizing and externalizing problems in the children were assessed with the Child Behavior Checklist at ages 11/2 and 3 y. Higher levels of maternal TSH during pregnancy predicted a higher externalizing scores in children at 11/2 and 3 y (B = 0.22 per SD of TSH; 95% CI: 0.04, 0.40; B = 0.10 per SD for internalizing scores; 95% CI:-0.01, 0.21). Maternal free thyroxine (T4) and total T4 were not associated with internalizing or externalizing scores of children. The linear relationship with more externalizing scores was across the range of TSH; this implies that subtle impairments of maternal thyroid function may affect the child. The results suggest that thyroid function is crucial for fetal brain development, which determines problem behavior later in life. Copyright </description>
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      <title>Predicting adult violent delinquency: Gender differences regarding the role of childhood behaviour (Article)</title>
      <link>http://repub.eur.nl/res/pub/34389/</link>
      <pubDate>2011-05-01T00:00:00Z</pubDate>
      <description>Adult violent delinquency harms individuals, their families and society at large. Knowledge about childhood predictors of adult delinquency could be helpful in defining at-risk children who will develop into violent adults. This topic is rarely investigated in females. We investigated which behavioural problems in childhood predicted long-term disruptive development in a sample of both males and females. In 1983, behaviour problems were assessed in a community sample of 2076 children; 24 years later, 1335 of these children, who are now adults, reported on their violent delinquency. Girls with conduct problems were at risk of long-term disruptive development. We recommend that health professionals be alert regarding girls with conduct problems, because early identification and treatment of high-risk girls might reduce delinquency in adult life.</description>
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      <title>Cross-cultural validity of the Scale for Interpersonal Behavior (Article)</title>
      <link>http://repub.eur.nl/res/pub/26738/</link>
      <pubDate>2011-03-01T00:00:00Z</pubDate>
      <description>The Scale for Interpersonal Behavior (SIB) is a 50-item multidimensional measure of difficulty and distress in assertiveness. The SIB assesses negative assertion, expression of and dealing with personal limitations, initiating assertiveness and positive assertion. The SIB was originally developed in the Netherlands. The present study attempted to replicate the original factors with an Italian student sample (n =995). The four distress and four performance factors were replicable across two methods of analysis (the multiple group method of confirmatory analysis and Tucker's coefficient of congruence φ). The corresponding scales were internally consistent and showed predicted patterns of correlations with a measure of self-efficacy. Sex and age differences in assertiveness were generally negligible. Italian students had higher positive assertion-performance scores than the Dutch and comparable scores on other performance scales; by contrast, the Italian subjects had significantly higher scores on all SIB distress scales than their Dutch equivalents. This was ascribed to the stronger pressure on people in Italian society to behave assertively (Hofstede's National Masculinity score = 70) as opposed to the Dutch society (National Masculinity score =14). </description>
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      <title>Childhood adversity modifies the relationship between anxiety disorders and cortisol secretion (Article)</title>
      <link>http://repub.eur.nl/res/pub/21837/</link>
      <pubDate>2010-12-01T00:00:00Z</pubDate>
      <description>Background Internalizing psychiatric disorders and early childhood adversity have both been associated with altered basal cortisol secretion. The aim of the present study is to investigate if early childhood adversity modifies the relationship between anxiety and mood disorders and cortisol secretion. Methods A sample of 429 international adoptees was followed from childhood to adulthood. In childhood, adoptive parents provided information about abuse and neglect before adoption. As adults, adoptees completed a standardized psychiatric interview to assess internalizing disorders and collected saliva samples four times a day. Analyses of covariance were performed. Results The relationship between anxiety disorders and cortisol secretion during 1 day, as measured by the area under the curve (AUC), was dependent on the experience of severe early maltreatment (p value of interaction = .03). In adoptees with an anxiety disorder, severe maltreatment was associated with lower daily cortisol secretion compared with nonmaltreated adoptees (respective AUC means: 28.19 and 36.96; difference = -8.78; confidence interval = -14.65 to -2.90; p = .004). In adoptees without an anxiety disorder, no difference in cortisol secretion was found between persons who did or did not experience severe maltreatment early in life (respective AUC means: 34.72 and 34.20; difference = .52; confidence interval = -1.92 to 2.96; p = .67). We found no modifying effect of severe early maltreatment on the relationship between mood disorders and daily cortisol secretion. Conclusions The experience of early adversities modifies the relationship between anxiety disorders and basal cortisol seretion in adults. To understand the relationship between anxiety disorders and cortisol secretion, early maltreatment has to be taken into account.</description>
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      <title>Adult outcomes of childhood dysregulation: A 14-year follow-up study (Article)</title>
      <link>http://repub.eur.nl/res/pub/21603/</link>
      <pubDate>2010-11-01T00:00:00Z</pubDate>
      <description>Objective Using a general population sample, the adult outcomes of children who presented with severe problems with self-regulation defined as being concurrently rated highly on attention problems, aggressive behavior, and anxious-depression on the Child Behavior ChecklistDysregulation Profile (CBCL-DP) were examined. Method Two thousand seventy-six children from 13 birth cohorts 4 to 16 years of age were drawn from Dutch birth registries in 1983. CBCLs were completed by parents at baseline when children from the different cohorts were 4 to 16 years of age and sampled every 2 years for the next 14 years. At year 14 the CBCL and DSM interview data were collected. Logistic regression was used to compare and contrast outcomes for children with and without dysregulation, as measured by the latent-classdefined CBCL-DP. Sex and age were covaried and concurrent DSM diagnoses were included in regression models. Results Presence of childhood CBCL-DP at wave 1 was associated with increased rates of adult anxiety disorders, mood disorders, disruptive behavior disorders, and drug abuse 14 years later. After controlling for co-occurring disorders in adulthood, associations with anxiety and disruptive behavior disorders with the CBCL-DP remained, whereas the others were not significant. Conclusions A child reported to be in the CBCL-DP class is at increased risk for problems with regulating affect, behavior, and cognition in adulthood.</description>
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      <title>Children's problems predict adults' DSM-IV disorders across 24 years (Article)</title>
      <link>http://repub.eur.nl/res/pub/28067/</link>
      <pubDate>2010-11-01T00:00:00Z</pubDate>
      <description>Objective The goal of this study was to determine continuities of a broad range of psychopathology from childhood into middle adulthood in a general population sample across a 24-year follow-up. Method In 1983, parent ratings of children's problems were collected with the Child Behavior Checklist (CBCL) in a general population sample of 2,076 children and young adolescents aged 4 to 16 years. In 2007, 24 years later, 1,339 of these individuals were reassessed with the CIDI, a standardized DSM-IV interview. We used univariate logistic regression analyses to determine the associations between children's problems and adults' psychiatric disorders. Results Parent reported total problems scores in the deviant range (&gt;85th percentile) predicted disruptive disorders in adulthood (odds ratio [OR] = 1.7, 95% confidence interval [95% CI] = 1.12.8). Adjusted for sex, age, and socioeconomic status in all analyses, deviant levels of parent-reported childhood anxiety predicted anxiety disorders in middle adulthood (OR = 1.6, 95% CI = 1.02.5). Conduct problems (i.e., cruelty to animals, lies) predicted both mood disorders (OR = 2.3, 95% CI = 1.14.8) and disruptive disorders (OR 2.1, 95% CI = 1.33.4), whereas oppositional defiant problems predicted only mood disorders (OR = 2.3, 95% CI = 1.05.2). Attention-deficit/hyperactivity problems did not predict any of the DSM-IV disorders in adulthood (OR = 0.8, 95% CI = 0.51.2). Conclusions Children with psychopathology are at greater risk for meeting criteria for DSM-IV diagnoses in adulthood than children without psychopathology, even after 24 years. Moreover, different types of continuities of children's psychopathology exist across the lifespan. We found that anxious children, oppositional defiant children, and children with conduct problems are at greater risk for adult psychopathology. Effective identification and treatment of children with these problems may reduce long-term continuity of psychopathology. </description>
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      <title>Developmental trajectories of child to adolescent externalizing behavior and adult DSM-IV disorder: results of a 24-year longitudinal study (Article)</title>
      <link>http://repub.eur.nl/res/pub/28216/</link>
      <pubDate>2010-10-11T00:00:00Z</pubDate>
      <description>Objective: Childhood externalizing behavior is found to be relatively persistent. Developmental pathways within types of externalizing behavior have been recognized from childhood to adolescence. We aimed to describe the prediction of adult DSM-IV disorders from developmental trajectories of externalizing behavior over a period of 24 years on a longitudinal multiple birth cohort study of 2,076 children. This has not been examined yet. Methods: Trajectories of the four externalizing behavior types aggression, opposition, property violations, and status violations were determined separately through latent class growth analysis (LCGA) using data of five waves, covering ages 4-18 years. Psychiatric disorders of 1,399 adults were assessed with the CIDI. We used regression analyses to determine the associations between children's trajectories and adults' psychiatric disorders. Results: All externalizing behavior types showed significant associations with disruptive disorder in adulthood. In all antisocial behavior types high-level trajectories showed the highest probability for predicting adult disorders. Particularly the status violations cluster predicted many disorders in adulthood. The trajectories most often predicted disruptive disorders in adulthood, but predicted also anxiety, mood, and substance use disorders. Conclusions: We can conclude that an elevated level of externalizing behavior in childhood has impact on the long-term outcome, regardless of the developmental course of externalizing behavior. Furthermore, different types of externalizing behavior (i.e., aggression, opposition, property violations, and status violations) were related to different adult outcomes, and children and adolescents with externalizing behavior of the status violations subtype were most likely to be affected in adulthood. </description>
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      <title>Perceived and physiological arousal during a stress task: Can they differentiate between anxiety and depression? (Article)</title>
      <link>http://repub.eur.nl/res/pub/20917/</link>
      <pubDate>2010-09-01T00:00:00Z</pubDate>
      <description>Background: Anxiety and depression might be two different valid constructs that often co-occur, or they could be different manifestations of the same underlying vulnerability. A theoretical framework to address this question is the tripartite model, by Clark and Watson, which hypothesizes that physiological hyperarousal (PH) is specific for anxiety. Knowledge about the relationship between PH, psychophysiological measures, perceived arousal, and anxiety would increase our understanding of the validity of the PH construct in this model. Our objective was to assess whether (a) hypothalamic-pituitary-adrenocortical (HPA) axis functioning, and (b) perceived arousal before, during and after stress can differentiate anxious from depressive children. Methods: In a general population sample of 225 children aged 8-12 years, self-reported anxiety and depressive symptoms were assessed using the Multidimensional Anxiety Scale for Children (MASC) and the Children's Depression Inventory (CDI). Perceived arousal was assessed using a self-report questionnaire before, during and after a stress task. Basal and reactive HPA-axis functioning were used as indices for psychophysiological arousal. Results: Our data showed that the relation between perceived arousal and anxiety problems is stronger than the relation with depressive problems. Reactive HPA-axis functioning is reduced in children with depressive problems. Conclusions: Some evidence was found in support of the tripartite model. Our findings indicate that perceived arousal to a challenge might be a useful tool to assess the PH component of the tripartite model. Reactive HPA-axis functioning might be able to differentiate between anxiety and depressive problems in children in a general population sample, but effect sizes are small and replication is needed.</description>
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      <title>Predicting adult emotional and behavioral problems from externalizing problem trajectories in a 24-year longitudinal study (Article)</title>
      <link>http://repub.eur.nl/res/pub/28306/</link>
      <pubDate>2010-07-01T00:00:00Z</pubDate>
      <description>The aim of this study was to examine the prediction of adult behavioral and emotional problems from developmental trajectories of externalizing behavior in a 24-years longitudinal population-based study of 2,076 children. The adult psychiatric outcome of these trajectories has not yet been examined. Trajectories of the four externalizing behavior types: aggression, opposition, property violations and status violations were determined separately through latent class growth analysis using data of five waves, covering ages 4-18 years. We used regression analyses to determine the associations between children's trajectories and adults' psychiatric problems based on the Adult Self-Report. The developmental trajectories of the four types of externalizing behavior mostly predicted intrusive, aggressive and rule-breaking behavior in adulthood. Non-destructive behaviors in childhood such as opposition and status violations predict adult problems to a larger extent than destructive behaviors such as aggression and property violations. In general, children who develop through high-level trajectories are likely to suffer from both internalizing and externalizing problem behavior in adulthood, regardless the direction of change (i.e. increasing/decreasing/persisting) of the high-level trajectory. We can conclude that the level rather than the developmental change of externalizing behavior problems has a larger impact on adult outcome. </description>
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      <title>Ethnic differences in mental health among incarcerated youths: Do Moroccan immigrant boys show less psychopathology than native Dutch boys? (Article)</title>
      <link>http://repub.eur.nl/res/pub/28333/</link>
      <pubDate>2010-05-01T00:00:00Z</pubDate>
      <description>Psychiatric disorders are highly prevalent among incarcerated youth. However, whereas ethnic minority youths are overrepresented in the juvenile justice system, limited research is available on their mental health. In this study, differences in mental health problems between incarcerated adolescents of native Dutch and Moroccan origin, were examined. Child Behavior Checklist and Youth Self-Report scores were compared between incarcerated adolescents of native Dutch and Moroccan origin. Their scores were also compared to those of native Dutch and Moroccan immigrant youths in the general, non-incarcerated population. Native Dutch incarcerated adolescents showed higher levels of various mental health problems than incarcerated adolescents with a Moroccan background. Compared to the general population, incarcerated youths showed higher levels of mental health problems, but this deviation was much larger for native Dutch than for Moroccan immigrant youths. These ethnic differences in mental health problems could not be explained by ethnic differences in socio-economic background and social desirable answering tendencies. Incarcerated youths of Moroccan origin show less psychopathology than incarcerated native Dutch youths, which might be explained by disparities in sentencing procedures. </description>
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      <title>A twin-singleton comparison of developmental trajectories of externalizing and internalizing problems in 6- to 12-year-old children (Article)</title>
      <link>http://repub.eur.nl/res/pub/33043/</link>
      <pubDate>2010-02-01T00:00:00Z</pubDate>
      <description>Research on twin-singleton differences in externalizing and internalizing problems in childhood is largely cross-sectional and yields contrasting results. The goal of this study was to compare developmental trajectories of externalizing and internalizing problems in 6- to 12-year-old twins and singletons. Child Behavior Checklist (CBCL) maternal reports of externalizing and internalizing problems were obtained for a sample of 9651 twins from the Netherlands Twin Register and for a representative general population sample of 1351 singletons. Latent growth modeling was applied to estimate growth curves for twins and singletons. Twin-singleton differences in the intercepts and slopes of the growth curves were examined. The developmental trajectories of externalizing problems showed a linear decrease over time, and were not significantly different for twins and singletons. Internalizing problems seem to develop similarly for twins and singletons up to age 9. After this age twins' internalizing symptoms start to decrease in comparison to those of singletons, resulting in less internalizing problems than singletons by the age of 12 years. Our findings confirm the generalizability of twin studies to singleton populations with regard to externalizing problems in middle and late childhood. The generalizability of studies on internalizing problems in early adolescence in twin samples should be addressed with care. Twinship may be a protective factor in the development of internalizing problems during early adolescence.</description>
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      <title>Cross-national comparison of the link between socioeconomic status and emotional and behavioral problems in youths (Article)</title>
      <link>http://repub.eur.nl/res/pub/19855/</link>
      <pubDate>2010-01-01T00:00:00Z</pubDate>
      <description>Introduction: In previous longitudinal studies in the US, lower socioeconomic status (SES) was associated with more emotional and behavioral problems. It remains unclear whether these findings can be generalized outside the US, as different countries vary in their health care systems and prevention of psychopathology in youth. Therefore, we studied the same associations in a comparable sample in The Netherlands and directly tested for differences between the US and The Netherlands. Methods: The US (N = 833) and Dutch (N = 708) population samples were followed-up for 9 years. Age at baseline ranged from 8 to 16 years. Parents filled out behavior checklists. Results: Analyses revealed very few differences between the two countries. In both countries, SES predicted syndrome scores and cumulative prevalence rates for internalizing and externalizing problems (withdrawn and aggressive behavior) and for thought and attention Problems. The SES gradient in syndrome scores was stable over time. Only for withdrawn behavior, the gradient was larger in young adulthood. Conclusion: Although the health care systems differ between the US and The Netherlands, the socioeconomic disparities in emotional and behavioral problems were similar.</description>
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      <title>Testing developmental pathways to antisocial personality problems (Article)</title>
      <link>http://repub.eur.nl/res/pub/25599/</link>
      <pubDate>2010-01-01T00:00:00Z</pubDate>
      <description>This study examined the development of antisocial personality problems (APP) in young adulthood from disruptive behaviors and internalizing problems in childhood and adolescence. Parent ratings of 507 children's (aged 6-8 years) symptoms of attention deficit hyperactivity disorder, oppositional defiant disorder, and anxiety, were linked to self-ratings of adolescents' (aged 14-16 years) symptoms of depression, substance use, conduct problems, and somatic problems, to predict self-ratings of APP in young adulthood (age 20-22 years). The findings suggested a hierarchical development of antisocial behavior problems. Despite being positively associated with conduct problems in adolescence, neither internalizing problems nor substance use added to the prediction of APP in young adulthood from conduct problems in adolescence. The developmental pathways to APP in young adulthood did not differ by gender.</description>
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      <title>Child to adult continuities of psychopathology: A 24-year follow-up (Article)</title>
      <link>http://repub.eur.nl/res/pub/24856/</link>
      <pubDate>2009-09-01T00:00:00Z</pubDate>
      <description>Objective: To determine continuities of mental health problems of children across a 24-year follow-up period. Method: In 1983, parent ratings of emotional and behavioral problems were collected with the Child Behavior Checklist (CBCL) in a general population sample of 2076 children. Twenty-four years later, 1365 participants completed Adult Self-Reports (ASR) to assess emotional and behavioral problems. Results: Of the participants who were classified as deviant in childhood, 22.2% were also classified as deviant in adulthood. Both homotypic and heterotypic continuity was found. Childhood aggressive, delinquent, and anxious\depressed problems were associated with most adult psychopathology. Attention problems did not predict later problems independently. Conclusion: Even though assessed with parent-reports in childhood and analogous self-reports in adulthood, and over a large period of 24 years, continuity of psychopathology was found from childhood into adulthood. Anxious\depressed problems, delinquent behavior and aggressive behavior in childhood are core predictors for adult psychopathology. </description>
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      <title>High activity of Monoamine oxidase A is associated with externalizing behaviour in maltreated and nonmaltreated adoptees (Article)</title>
      <link>http://repub.eur.nl/res/pub/24751/</link>
      <pubDate>2009-08-01T00:00:00Z</pubDate>
      <description>Individual differences in a functional polymorphism of the promoter of the Monoamine oxidase A (MAO-A) gene might partly explain the increased vulnerability of maltreated children for externalizing behaviour. A sample of 239 internationally adopted boys was studied. Adoptive parents provided the information about abuse and neglect before the adoption and rated externalizing behaviour of their adopted children, using the Child Behaviour Checklist. MAO-A alleles were classified in high and low activity. We found that individuals with high MAO-A activity had more externalizing behaviour than those with low MAO-A activity. No modifying effect of MAO-A on the relationship between early maltreatment on externalizing behaviour was observed. Our results suggest that in severely maltreated children, high MAO-A activity may not protect against the effects of maltreatment but may convey an increased risk for externalizing behaviour. </description>
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      <title>Paternal depressive symptoms during pregnancy are related to excessive infant crying (Article)</title>
      <link>http://repub.eur.nl/res/pub/25405/</link>
      <pubDate>2009-07-01T00:00:00Z</pubDate>
      <description>OBJECTIVE: Excessive infant crying, or infantile colic, is a common and often stress-inducing problem for parents that can ultimately result in child abuse. From previous research it is known that maternal depression is related to excessive crying, but so far little is known about the influence of paternal depression. METHODS: In a prospective, population-based study, we obtained information on both maternal and paternal depressive symptoms at 20 weeks of pregnancy by using the Brief Symptom Inventory. Parental depressive symptoms were related to excessive crying in 4426 two-month-old infants. The definition of excessive crying was based on the widely used Wessel's criteria (ie, crying &gt;3 hours for &gt;3 days in the past week). RESULTS: After adjustment for depressive symptoms of the mother and relevant confounders, we found a 1.29 (95% confidence interval: 1.09-1.52) higher risk of excessive infant crying per SD of paternal depressive symptoms. CONCLUSIONS: Our findings indicate that paternal depressive symptoms during pregnancy might be a risk factor for excessive infant crying. This finding could be related to genetic transmission, interaction of a father with lasting depressive symptoms with the infant, or related indirectly through contextual stressors such as marital, familial, or economic distress. Copyright </description>
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      <title>Early neglect and abuse predict diurnal cortisol patterns in adults. A study of international adoptees (Article)</title>
      <link>http://repub.eur.nl/res/pub/24496/</link>
      <pubDate>2009-06-01T00:00:00Z</pubDate>
      <description>Neglect and abuse early in life have been associated with increased and decreased cortisol levels, and also with an altered diurnal cortisol slope. In the present study, we investigated the long-term relationship between early maltreatment - at different levels of severity - and basal cortisol secretion in adults adopted as children. A sample of international adoptees was followed from childhood to adulthood. In childhood, adoptive parents had provided information about neglect and abuse prior to adoption. As adults, adoptees collected saliva samples four times a day. The relationship between early maltreatment and cortisol secretion was examined, primarily with multilevel analyses in 623 adoptees. Morning cortisol levels were lower in adoptees whose adoptive parents had reported severe neglect or abuse than in non-neglected or non-abused participants (respective estimates (standard errors (SEs)) and p-values: -0.33 (0.090), p = 0.0002 and -0.63 (0.20), p = 0.002). Relative to non-neglected adoptees, those who had allegedly experienced severe neglect also had a flatter diurnal slope (estimate (SE) and p-value: 0.028 (0.0088), p = 0.002). In contrast, relative to non-abused participants, adoptees whose reported abuse was moderately severe had high cortisol levels and a steeper cortisol diurnal slope (respective estimates (SEs) and p-values: 0.29 (0.13), p = 0.003 and -0.039 (0.012), p = 0.01). Thus, early neglect and abuse appear to have associations with cortisol levels and the diurnal slope, even when children are raised in another environment after their early maltreatment. Our study suggests that the severity of the early maltreatment may be related to the basal cortisol pattern. </description>
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      <title>Impact of early childhood adversities on adult psychiatric disorders (Article)</title>
      <link>http://repub.eur.nl/res/pub/24146/</link>
      <pubDate>2009-02-12T00:00:00Z</pubDate>
      <description>Background: This study investigated international adoptees who were taken out of their problematic environments as a consequence of their adoption to determine the effects of early adversities on adult psychiatric disorders, and to study whether these effects emerged de novo after childhood. Methods: A total of 1,364 adoptees (63.5% of the baseline sample) were followed. Parents provided information about early adversities prior to adoption, and mental health problems in childhood and adolescence. In adulthood, adoptees completed a standardized interview, generating DSM-IV diagnoses. Results: Children who experienced multiple adversities had an increased risk of having anxiety disorders (OR = 2.22; 95% CI: 1.11-4.45), mood disorders (OR = 2.20; 95% CI: 1.00-4.86) or substance abuse/dependence (OR = 3.81; 95% CI: 1.62-8.98) in adulthood. Several effects remained significant after correction for mental health problems in childhood and adolescence. Conclusions: Severe early adversities increase the risk ofadult psychopathology, even when children are taken out of their problematic environments. Results suggest that psychiatric disorders may arise de novo after childhood due to early experiences. </description>
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      <title>Early childhood adversities and trajectories of psychiatric problems in adoptees: Evidence for long lasting effects (Article)</title>
      <link>http://repub.eur.nl/res/pub/24218/</link>
      <pubDate>2009-02-01T00:00:00Z</pubDate>
      <description>The aim of the present study is to investigate whether early childhood adversities determine the longitudinal course of psychiatric problems from childhood to adulthood; in particular if the impact of early maltreatment on psychopathology decreases as time passes. A sample of 1,984 international adoptees was followed (955 males and 1029 females; adopted at the mean age of 29 months). Parents provided information about abuse, neglect and number of placements prior to adoption at baseline and completed the Child Behavior Checklist or the Young Adult Behavior Checklist three times when their children were between 10 and 30 years of age. Multilevel analyses were performed to determine trajectories of psychiatric problems. Experience of early childhood adversity prior to adoption substantially increased the level of psychiatric problems, especially when maltreatment was severe. Moreover, the impact of early adversities on psychiatric problems remained markedly stable. This suggests that vulnerability of early-maltreated children persists even if they are taken out of their problematic environments and are raised in enriched circumstances.</description>
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      <title>Intergenerational transmission of child problem behaviors: A longitudinal, population-based study (Article)</title>
      <link>http://repub.eur.nl/res/pub/27124/</link>
      <pubDate>2009-02-01T00:00:00Z</pubDate>
      <description>Objective: From a developmental perspective, it is important to know to what extent childhood problem behaviors are transmitted across generations. In a longitudinal community study, we compared child behavior of parents with the behavior of their offspring. Intergenerational transmission was investigated for a broad range of problem behaviors, including internalizing problems and externalizing behavior. Sex differences were investigated as well. Method: We compared Child Behavior Checklist scores of 4- to 16-year-old children (N= 271) from a community sample assessed in 1983 with Child Behavior Checklist scores of their 6- to 18-year-old offspring (N = 424) who were assessed in 2007. Multilevel modeling was used to test intergenerational associations. Results: Most forms of problem behavior in children were predicted by the behavior of their parents as children. Parents' Internalizing, Externalizing, and Total Problem scores in childhood all predicted similar problems in their children. Sex differences were found for Delinquent Behavior: continuity was stronger in mothers than it was in fathers, and it was also stronger in sons than in daughters. Conclusions: The finding that child behavior continues across generations poses challenges in finding ways to prevent problems from being transmitted across generations. </description>
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      <title>Beliefs about mental health problems and help-seeking behavior in Dutch young adults (Article)</title>
      <link>http://repub.eur.nl/res/pub/22881/</link>
      <pubDate>2009-01-01T00:00:00Z</pubDate>
      <description>Abstract

BACKGROUND: Mental health problems in young adults are frequent and impairing, but are often left untreated. This study among young adults with self-perceived mental health problems examines beliefs about mental health problems (i.e. their cause, consequences, timeline, and controllability) and help-seeking behaviour.

METHOD: A cross-sectional population survey (n = 2,258) in the south-west Netherlands. Participants were included who reported having mental health problems during the past year (n = 830). Beliefs about cause, consequences, timeline, and controllability of self-perceived mental health problems were assessed with the Illness Perception Questionnaire. Internalizing and externalizing psychopathology was assessed with the Adult Self-Report.

RESULTS: A multivariate logistic regression analysis indicates that independent of sex, age, and severity of psychopathology, higher levels on the intra-psychic causes scale (OR = 1.95, 95%CI = 1.48-2.58), the consequences scale (OR = 1.81, 95%CI = 1.40-2.33), and the treatment control scale (OR = 1.97, 95%CI = 1.60-2.41) are associated with an increased likelihood of mental health service use, while higher levels of personal control (OR = 0.76, 95%CI = 0.62-0.93) are associated with a decreased likelihood.

CONCLUSIONS: Beliefs that may encourage young adults with mental health problems to seek professional help include the beliefs that mental health problems have adverse consequences and that treatment can help. Since these beliefs are related to young adults' knowledge of mental health problems, help-seeking behavior may be encouraged by educating young adults about mental health problems and the effective mental health treatments which are available.</description>
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      <title>Young adults face major barriers to seeking help from mental health services (Article)</title>
      <link>http://repub.eur.nl/res/pub/29802/</link>
      <pubDate>2008-10-01T00:00:00Z</pubDate>
      <description>Objective: Mental health problems often emerge in young adulthood. Although effective treatments are available, young adults are unlikely to seek professional help. This study examined barriers-to-care in young adults with serious internalizing or externalizing problems. Methods: Population-based study among 2258 19-32-year olds in the south-west region of the Netherlands. Barriers-to-care were examined in participants with serious internalizing or externalizing problems who did not seek professional help. A potential barrier was that participants denied that they had mental health problems. In those admitting problems, barriers were assessed with the Barriers-to-Care checklist and analyzed with Latent Class Analysis. Results: Of 362 participants with serious internalizing or externalizing problems 237 (65.5%) did not seek professional help. Of non-help-seeking young adults 36% denied having problems; additionally Latent Class Analysis revealed that 37% Perceived Problems as Self-Limiting (e.g., they believed that problems were not serious) and 24% Perceived Help-Seeking Negatively (e.g., they believed that treatment would not help). Conclusions: Young adults' barriers-to-care reflect limitations in their knowledge of mental health problems and available treatments, but possibly also a failure of existing mental health services to engage young people. More knowledge is urgently needed about the effectiveness of mental health treatments for young adults specifically. Practice implications: Treatment accessibility for young adults may be augmented by improving their mental health literacy. </description>
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      <title>Ten-year increase in service use in the Dutch population (Article)</title>
      <link>http://repub.eur.nl/res/pub/30155/</link>
      <pubDate>2008-09-01T00:00:00Z</pubDate>
      <description>Since earlier research has indicated an increase in mental health problems among Dutch children, we investigated whether service use for mental health problems has also increased. Subsequently, we investigated whether a possible increase could be explained by child, family and socio-demographic characteristics that increase the likelihood of service use. We compared two population samples of 6- to 18-year-olds, one assessed in 1993 and one in 2003. Chi-square tests were conducted to examine differences between the proportions of service-users. We performed a logistic regression to test whether care-promoting factors accounted for the effect of year. Results showed that service use increased from 1993 to 2003, but not among children with high CBCL scores. Having serious problems, living in a family other than two biological parents, and having educational problems all increased the likelihood of service use and became more present in the Dutch population. These variables accounted for 49% reduction in the Odds Ratio of the effect of year. Although the proportion of children who used services increased from 1993 to 2003, still a large number of children experience an unmet need. The increase in the number of children from a family structure other than two biological parents or who have educational problems is a worrisome development in itself. </description>
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      <title>Associations between ethnicity and self-reported hallucinations in a population sample of young adults in The Netherlands (Article)</title>
      <link>http://repub.eur.nl/res/pub/32382/</link>
      <pubDate>2008-08-01T00:00:00Z</pubDate>
      <description>Background: Psychotic disorders are more common in people from ethnic minorities. If psychosis exists as a continuous phenotype, ethnic disparities in psychotic disorder will be accompanied by similar ethnic disparities in the rate of psychotic symptoms. This study examined ethnic disparities in self-reported hallucinations in a population sample of young adults. Method: A cross-sectional population survey (n=2258) was carried out in the south-west Netherlands. Seven ethnic groups were delineated: Dutch natives, Turks, Moroccans, Surinamese/Antilleans, Indonesians, other non-Western immigrants (mostly from Africa or Asia) and Western immigrants (mostly from Western Europe). Self-reported auditory and visual hallucinations were assessed with the Adult Self-Report (ASR). Indicators of social adversity included social difficulties and a significant drop in financial resources. Results: Compared to Dutch natives, Turkish females [odds ratio (OR) 13.48, 95% confidence interval (CI) 5.97-30.42], Moroccan males (OR 8.36, 95% CI 3.29-21.22), Surinamese/Antilleans (OR 2.19, 95% CI 1.05-4.58), Indonesians (OR 4.15, 95% CI 1.69-10.19) and other non-Western immigrants (OR 3.57, 95% CI 1.62-7.85) were more likely to report hallucinations, whereas Western immigrants, Turkish males and Moroccan females did not differ from their Dutch counterparts. When adjusting for social adversity, the ORs for self-reported hallucinations among the non-Western immigrant groups showed considerable reductions of 28% to 52%. Conclusions: In a general population sample, several non-Western immigrant groups reported hallucinations more often than Dutch natives, which is consistent with the higher incidence of psychotic disorders in most of these groups. The associations between ethnicity and hallucinations diminished after adjustment for social adversity, which supports the view that adverse social experiences contribute to the higher rate of psychosis among migrants. Copyright </description>
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      <title>Predicting young adult social functioning from developmental trajectories of externalizing behaviour (Article)</title>
      <link>http://repub.eur.nl/res/pub/32350/</link>
      <pubDate>2008-07-01T00:00:00Z</pubDate>
      <description>Background. The long-term consequences of child and adolescent externalizing problems often involve a wide spectrum of social maladaptation in adult life. The purpose of this study was to describe the predictive link of child and adolescent externalizing developmental trajectories to social functioning in adulthood. Method. Social functioning was predicted from developmental trajectories of parent-reported aggression, opposition, property violations and status violations that were defined in a longitudinal multiple birth cohort study of 2076 males and females aged 4-18 years. Social functioning was assessed using self-reports by young adults aged 18-30 years. Linear and logistic regression analyses were used to describe the extent to which developmental trajectories are prospectively related to social functioning. Results. Children with high-level trajectories of opposition and status violations reported more impaired social functioning as young adults than children with high-level trajectories of aggression and property violations. Young adults who showed onset of problems in adolescence reported overall less impaired social functioning than individuals with high-level externalizing problems starting in childhood. Overall, males reported more impaired social functioning in adulthood than females. However, females with persistent high-level externalizing behaviour reported more impairment in relationships than males with persistent high-level externalizing behaviour. Conclusion. The long-term consequences of high levels of opposition and status violations in childhood to serious social problems during adulthood are much stronger than for individuals who show only high levels of aggressive antisocial behaviours. Copyright </description>
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      <title>With reply (Article)</title>
      <link>http://repub.eur.nl/res/pub/15120/</link>
      <pubDate>2008-07-01T00:00:00Z</pubDate>
      <description></description>
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      <title>Ten-year trends in self-reported emotional and behavioral problems of Dutch adolescents (Article)</title>
      <link>http://repub.eur.nl/res/pub/29965/</link>
      <pubDate>2008-05-01T00:00:00Z</pubDate>
      <description>Background: Research comparing population samples from different time periods to investigate secular changes in adolescents' psychosocial problems have mostly focused on parent and teacher reports. The few studies using self-reports have limitations, such as using only school-based samples or investigating a limited range of problems. Aim: We investigated changes from 1993 to 2003 in Dutch 11- to 18-year-old girls' and boys' self-reported emotional and behavioral problems. We also examined whether trends were different for various socio-demographic groups. Method: We used the Youth Self-Report (YSR) to assess emotional and behavioral problems, and obtained self-reports of police contact, substance abuse, suicidal ideation and self-harm across two adolescent population samples, assessed in 1993 and 2003. To investigate whether reports were different for the 2 years, we performed analyses of variance on the mean scores, and chi-square analyses on the percentages of deviant-scoring children and children reporting specific problem behaviors for boys and girls separately. Logistic regressions were conducted to investigate interactions of year with various socio-demographic variables. Results: For boys, results showed a few small changes, indicating decreases from 1993 to 2003 in self-reported Social Problems, Externalizing, Aggressive Behavior, and Rule- Breaking Behavior. For girls, Thought problems, Somatic Complaints, Internalizing problems, suicidal ideation and self-harm increased. Drunkenness and drug use increased for both boys and girls. There were some differences between socio-demographic groups. Boys from low-SES families and younger adolescent girls experienced most increases. Conclusion: We found evidence for some small trends in self-reported problems. For boys, some decreases were seen, regarding mostly behavioral problems, whereas for girls, some increases were seen in emotional and behavioral problems. Changes appeared to have most negatively affected young adolescent girls' functioning. </description>
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      <title>Parent-reported sleep problems during development and self-reported anxiety/depression, attention problems, and aggressive behavior later in life (Article)</title>
      <link>http://repub.eur.nl/res/pub/32443/</link>
      <pubDate>2008-04-01T00:00:00Z</pubDate>
      <description>Objective: To examine associations between sleep problems during development and subsequent emotional and behavioral difficulties. Design: Prospective longitudinal study. Setting: The Dutch province of Zuid-Holland. Participants: At time 1 of data collection, a representative sample of 2076 children aged 4 to 16 years participated in the study. Outcome Measures: Parents rated their children's (4-19 years old) sleep at 5 assessments by completing the Child Behavior Checklist. Participants reported on their own emotional and behavioral symptoms at a later assessment (when aged 18-32 years) by completing the Young Adult Self-Report. Results: After adjusting for sex, age, socioeconomic status, and parent-rated scores through development for the difficulty being predicted, having any parental reports of sleeping less than others was a risk indicator of high scores on the Anxious/Depressed scale (odds ratio, 1.43; 95% confidence interval, 1.07-1.90; P=.01) and the Aggressive Behavior scale (odds ratio, 1.51; 95% confidence interval, 1.13-2.02; P=.005). There was some (albeit less robust) support for links between other reported sleep difficulties and later problems. Parental reports of sleeping more than others and nightmares were not associated with later difficulties. Conclusions: Physicians should inquire about sleep problems during child development and should be aware that some, but perhaps not others, may constitute risk indicators of later difficulties. </description>
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      <title>Genetic and environmental influences on self-reported and parent-reported behavior problems in young adult adoptees (Article)</title>
      <link>http://repub.eur.nl/res/pub/30492/</link>
      <pubDate>2008-02-01T00:00:00Z</pubDate>
      <description>The aim of the present study was to estimate the genetic, shared and nonshared environmental contributions to self-reported and parent-reported internalizing and externalizing problems in a follow-up study of intercountry adopted young adults. Young Adult Self-Report ratings were obtained from 1475 adoptees aged 22-32 years and Young Adult Behavior Checklist ratings from 1115 adoptive parents. For the genetic analyses, a subset of 143 adopted biologically related and 295 unrelated siblings was used. The data were subjected to model fitting decomposing three sources of variance: genetic factors (A) shared environment (C) and nonshared environment (E). Genetic factors were of more importance in both self-reported (A2= 54%, C2= 0, and E2= 46%) and parent-reported (A2= 76%, C2= 15% and E2= 9%) internalizing problems. Environmental factors were of more importance in both self-reported (A2= 33%, C2= 17% and E2= 50%) and parent-reported (A2= 28%, C2= 27% and E2= 45%) externalizing problems. This was in contrast with findings from the first and second assessments in the same sample during adolescence when genetic factors were more important in explaining externalizing problems compared with internalizing problems. Our results suggest a developmental reversal in genetic and environmental influences on behavior problems from early adolescence into adulthood, which could be related to different underlying developmental trajectories. </description>
    </item> <item>
      <title>Twenty-year trends in emotional and behavioral problems in Dutch children in a changing society (Article)</title>
      <link>http://repub.eur.nl/res/pub/35075/</link>
      <pubDate>2007-12-01T00:00:00Z</pubDate>
      <description>Objective: Research into changes in the prevalence of children's psychiatric diagnoses has indicated an increase in recent decades. However, methodological problems may have influenced results. This study compared children's emotional and behavioral problem levels across three population samples from different time points across 20 years, assessed with identical methodologies. Method: We compared Child Behavior Checklists and Teacher's Report Forms across three population samples of 6- to 16-year olds, assessed in 1983, 1993, and 2003. Results: We found evidence for small increases in the mean population levels of parent-reported problems, and in the percentages of children with serious problems. These changes concerned mostly internalizing problems. Teacher reports showed less changes. Decreases in scores were found on several areas of competence. Changes were the strongest between 1993 and 2003. Conclusion: We found evidence for small increases in Dutch children's problems. Further developments must be monitored, as this trend may continue and have serious societal consequences. </description>
    </item> <item>
      <title>Ethnic disparities in mental health and educational attainment: Comparing migrant and native children (Article)</title>
      <link>http://repub.eur.nl/res/pub/35126/</link>
      <pubDate>2007-11-01T00:00:00Z</pubDate>
      <description>Study background and aims: Ethnic disparities in mental health in adolescence may play a role in the development of ethnic disparities in educational attainment. The aim of this study was to assess the contribution of ethnic disparities in mental health problems in adolescence to ethnic disparities in educational attainment in adulthood. Methods: We followed two community samples of respectively 486 Dutch native and 168 Turkish migrant adolescents (11-15 years old) into adulthood (21-25 years old). Mental health was measured in adolescence, and educational attainment was assessed in adulthood. The contribution of mental health disparities to educational disparities was estimated by the degree of attenuation of the odds ratio (OR) for low education after adjustment for mental health problems. Results: Adult Turkish men more often had attained lower education than Dutch men (OR 1.81 (1.01-3.25)). Additional adjustment for mental health problems during adolescence did not change the OR. In Turkish women, however, the OR was 1.94 (1.04-3.62), and adjustment for mental health problems lowered it by 96% to 1.04 (0.51-2.14). The contribution was mostly due to ethnic disparities in internalizing problems. Conclusion: In women, but not in men, ethnic disparities in mental health, especially internalizing problems, were a strong predictor for the development of ethnic disparities in educational attainment. Prevention or treatment of internalizing problems among Turkish girls will probably contribute to the prevention of educational disparities. </description>
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      <title>Long-term associations of childhood suicide ideation (Article)</title>
      <link>http://repub.eur.nl/res/pub/36241/</link>
      <pubDate>2007-11-01T00:00:00Z</pubDate>
      <description>OBJECTIVE: We investigated in a prospective longitudinal population-based study whether childhood suicide ideation is associated with negative mental health outcome in adulthood. METHOD: A total of 1,022 Dutch children who were 11 years or younger in 1983 were prospectively followed over 10 to 14 years into adulthood. Parent reports of suicide ideation in childhood (11 years or younger; n = 20) were examined in relation to mental health in adulthood assessed with a structured psychiatric interview (mood disorder, anxiety disorder, alcohol abuse/dependence, and externalizing disorder) and self-reported suicide ideation and history of suicide attempt. RESULTS: Childhood suicide ideation was highly predictive of suicide ideation in adulthood (odds ratio 10.70, 95% confidence interval 3.26-35.09), and lifetime history of suicide attempt (odds ratio 5.80, 95% confidence interval 1.53-22.02). Childhood suicide ideation was associated with an increased likelihood of mood disorder and anxiety disorder in adulthood and to a lesser extent externalizing disorder, although these effects decreased considerably after adjusting for childhood internalizing and externalizing behavior. CONCLUSIONS: Suicide ideation in childhood may be a stable characteristic with worrying consequences in adulthood. Children with parent-reported suicide ideation at a young age may require additional resources, age-appropriate intervention, and careful monitoring into adulthood. Copyright 2007 </description>
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      <title>14-Year changes in emotional and behavioral problems of very young Dutch children (Article)</title>
      <link>http://repub.eur.nl/res/pub/36248/</link>
      <pubDate>2007-10-01T00:00:00Z</pubDate>
      <description>OBJECTIVE: The societal changes experienced by Western societies in recent decades have raised concerns about increases in the level of children's mental health problems. Although studies of secular changes in the prevalence of psychiatric diagnoses have indeed shown increases, their results may have been influenced by methodological problems, such as changing diagnostic criteria. Although repeated population studies using identical measures have not indicated such a clear increase in mental health problems, these studies have been limited to school-age children. We therefore investigated changes in Dutch parents' reports of very young children's emotional and behavioral problems over a 14-year period. METHOD: We compared Child Behavior Checklist scores across two Dutch general population samples of 2- and 3-year-olds, one sample assessed in 1989 and one in 2003. RESULTS: Results revealed only a few changes over time, indicating small decreases in parent-reported problems. Between 1989 and 2003, there were decreases in the mean scores and in the proportions of children with deviant scores on the Anxious/Depressed, Total Problems, Internalizing, and DSM-oriented attention-deficit/hyperactivity problems scales. CONCLUSIONS: Despite indications of increasing problems among school-age children and adolescents, parent-reported problem levels of very young Dutch children have not increased. Our findings even showed some small improvements in parents' reports of very young children's functioning between 1989 and 2003. Copyright 2007 </description>
    </item> <item>
      <title>The different stages and actors involved in the process leading to the use of adolescent mental health services (Article)</title>
      <link>http://repub.eur.nl/res/pub/36764/</link>
      <pubDate>2007-10-01T00:00:00Z</pubDate>
      <description>Although a substantial number of adolescents suffer from emotional or behavioural problems, only a minority receive mental health care. In order to understand this discrepancy, this article aims to increase insight into the help-seeking process. First, a model of the help-seeking process for adolescent psychopathology was formulated. This model takes into account the sequential nature of help seeking and the involvement of multiple actors (adolescents, parents and teachers) and service providers (general practitioners, mental health care professionals, teachers, and friends/relatives). Using structural equation modelling, the model was empirically tested on 114 Dutch adolescents (aged 12-17 years), who were selected for having emotional or behavioural problems from a representative general practice sample. Of these 16.5% had used mental health services. The sequence of stages and the actors involved in the process leading to mental health care use was similar across gender. Parents and adolescents had a comparable impact on this process. The general practitioner functioned as gatekeeper to mental health care, whereas the teacher's role in the process was limited. Interventions aimed at increasing adolescent mental health service use should be directed at parents and adolescents, and at the roles of school personnel and general practitioners in the detection of problems and referral. Copyright </description>
    </item> <item>
      <title>Developmental trajectories of depressive symptoms from early childhood to late adolescence: Gender differences and adult outcome (Article)</title>
      <link>http://repub.eur.nl/res/pub/35328/</link>
      <pubDate>2007-07-01T00:00:00Z</pubDate>
      <description>Backround: Limited information is available on gender differences and young-adult poor outcome in children and adolescents following distinct developmental trajectories of depressive symptoms. Methds: Parent information on depressive symptoms of 4- to 18-year-olds from an ongoing Dutch community-based longitudinal multiple-cohort study (N=2,076) was used to estimate trajectories from semi-parametric mixture models. The identified trajectories were used to predict depressive problems, general mental health problems, referral to mental health care, and educational attainment in young adulthood. Results: In both genders six distinct developmental trajectories were identified. Gender differences existed not only in level, but also in shape and timing of onset of depressive problems. Only in girls was a chronic trajectory of early childhood-onset depression identified. In both boys and girls a group with increasing levels of depressive symptoms was identified that reached a high level around adolescence, although boys showed an earlier onset. Two decreasing trajectories were found in boys, one reaching normative levels of depressive symptoms around late childhood and one around mid-adolescence, while none was found for girls. Individuals who followed elevated trajectories during their whole childhood or starting at adolescence had significantly more depressive and other mental health problems in young adulthood compared to those who followed normative trajectories. Boys in these elevated trajectories showed lower educational attainment, while girls were more likely to have been referred to mental health care. Conclusions: This study shows the value of estimating growth-mixture models separately for boys and girls. Girls with early childhood or adolescence-onset depressive problems and boys with depressive problems during childhood or starting in adolescence are especially at risk for poor outcome as young adults and should be considered candidates for intervention. © 2007 The Authors Journal compilation </description>
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      <title>Which better predicts conduct problems? The relationship of trajectories of conduct problems with ODD and ADHD symptoms from childhood into adolescence (Article)</title>
      <link>http://repub.eur.nl/res/pub/35401/</link>
      <pubDate>2007-06-01T00:00:00Z</pubDate>
      <description>Background: To assess the co-occurrence in deviant trajectories of parent-rated symptoms of conduct disorder (CD), oppositional defiant disorder (ODD) and attention-deficit/hyperactivity disorder (ADHD) from age 4 to 18 years old in a general population sample of Dutch children. Methods: Developmental trajectories of CD, ODD, and ADHD were estimatedin a sample of 1,016 males and 1,060 females. Children's disruptive problem behaviors were rated at 5 time-points. The co-occurrence patterns between the deviant CD trajectory, and the high ODD and high ADHD trajectory were studied for males and females separately. Results: Four percent of males and 2% of females followed a deviant CD trajectory. Six percent of the sample followed a high ODD trajectory, and 5% a high ADHD trajectory. Engagement in the deviant CD trajectory was predicted by ODD and ADHD in females, but only by ODD in males. Conclusions: Although ADHD co-occurs with CD, the association between ADHD and CD is largely accounted for by accompanying ODD. Gender differences should be taken into account in understanding the onset of CD. © 2007 The Authors Journal compilation </description>
    </item> <item>
      <title>Social functioning of bipolar offspring (Article)</title>
      <link>http://repub.eur.nl/res/pub/35840/</link>
      <pubDate>2007-03-01T00:00:00Z</pubDate>
      <description>Background: Bipolar patients have impaired social functioning compared to people in the general population. It has been suggested that children of bipolar patients also have impaired social functioning. The objective of this study was to compare social functioning of adolescent and young adult offspring of bipolar parents with social functioning of adolescents and young adults in the general population. Method: Subjects were 140 offspring of bipolar parents and 1122 adolescents and 1175 young adults from the general population. Parent, teacher and self-report ratings were used to assess social functioning. Results: Analyses revealed no differences in scores on social functioning for offspring aged 11 to 18 years, and few differences for ages 18 to 26 years compared to same aged individuals from the general population. Offspring with a DSM-IV disorder showed a lower level of social functioning compared to Dutch subjects from the general population in the same age range. Limitations: The limitations of this study are lack of information on the representativeness of the sample and use of one measure for social functioning. Conclusions: Bipolar offspring in the adolescent age range have good overall level of social functioning. Social functioning in offspring aged 18 years or older with a bipolar or other mood disorder is impaired. </description>
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      <title>Parent-teacher disagreement regarding behavioral and emotional problems in referred children is not a risk factor for poor outcome (Article)</title>
      <link>http://repub.eur.nl/res/pub/36687/</link>
      <pubDate>2007-03-01T00:00:00Z</pubDate>
      <description>Objective: To investigate whether parent-teacher disagreement regarding the presence of psychopathology predicts poor outcome in children who have been referred to mental health services Methods: A total of 532 6- to 12-year-old children who had been referred to an outpatient department for child and adolescent psychiatry were followed up across an average period of 6.3 years. At initial assessment, standardized parent and teacher ratings of the child's psychopathology were obtained with the Child Behavoir Checklist (CBCL) and Teacher's Reprot form (TRF). At follow-up, indices of poor outcome were assessed. Results: Several CBCL and TRF scale scores predicted poor outcome. Discrepancies between CBCL and TRF scores were not useful as additional predictors. Some additive effects were found; future police/judicial contacts and disciplinary problems in school were predicted by CBCL and TRF scores. Conclusions: The findings underscored the need for information from different informants in clinical practice. However, discrepancies between parent and teacher ratings do not predict outcome, and should not alert clinicians. </description>
    </item> <item>
      <title>Development of ethnic disparities in internalizing and externalizing problems from adolescence into young adulthood (Article)</title>
      <link>http://repub.eur.nl/res/pub/35590/</link>
      <pubDate>2007-02-01T00:00:00Z</pubDate>
      <description>Background: Little is known about changes in ethnic disparities in mental health during the development of adolescents into young adults. The aim of this study was to study the development of disparities in internalizing and externalizing problems between Dutch natives and Turkish migrant children from adolescence into adulthood. Methods: Turkish migrants (n = 217) and Dutch natives (n = 723) completed two comparable questionnaires about internalizing and externalizing problems: the Youth Self-Report at age 11-18 and the (Young) Adult Self-Report ten years later, at age 21-28. We used mixed linear regression models to model development of mental health problems and to test changes in disparities in mental health between Turkish migrants and Dutch natives. Results: Both in adolescence and in adulthood migrants reported more internalizing and externalizing problems than natives, most pronounced for internalizing problems. Disparities decreased from adolescence into adulthood for both internalizing problems (-52%, p &lt;.0001) and externalizing problems (-67%, p =.01), independently of gender, age, country of birth of Turkish adolescents, and parental socio-economic position. The favorable changes in the disparities over time were due to more favorable development among Turkish migrants than among natives. Conclusion: In this prospective study, ethnic disparities in internalizing and externalizing problems decreased as adolescents entered adulthood. Different explanations are discussed. </description>
    </item> <item>
      <title>Perceived parental rearing of bipolar offspring (Article)</title>
      <link>http://repub.eur.nl/res/pub/35638/</link>
      <pubDate>2007-01-01T00:00:00Z</pubDate>
      <description>Objective: To explore the impact of growing up with a parent with a bipolar disorder. First, we compared parental rearing behavior perceived by young adult offspring of bipolar parents with parental rearing behavior perceived by same aged young adults from the general population. Secondly, we examined the associations between perceived parental rearing behavior and parental psychopathology and psychopathology in offspring. Method: Subjects were 129 offspring of 80 bipolar parents and their spouses and 1122 young adults from the general population. In offspring the Structured Clinical Interview for DSM-IV was used to assess DSM-IV diagnoses and the EMBU was used to assess perceived parental rearing in both groups. Results: In general, offspring growing up in a family with a bipolar parent perceived their mothers as less rejecting, more emotionally warm and less overprotecting and their fathers as less emotionally warm and less overprotecting compared with young adults from the general population. Perceived rejection was related to psychopathology in offspring. Conclusion: Overall, parental rearing in families with a parent with a bipolar disorder is not more dysfunctional, as perceived by their offspring, than in families from the general population. Offspring with a bipolar disorder perceive their parents as more rejecting. </description>
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      <title>Parent-teacher disagreement regarding psychopathology in children: A risk factor for adverse outcome? (Article)</title>
      <link>http://repub.eur.nl/res/pub/35669/</link>
      <pubDate>2007-01-01T00:00:00Z</pubDate>
      <description>Objective: To investigate if parent-teacher discrepancies in reports of behavioral/emotional problems in children predict poor outcome. Method: A total of 1154 4- to 12-year-old children from the general population were followed up. At the first assessment, parent and teacher ratings were obtained with the Child Behavior Checklist (CBCL) and Teacher's Report Form (TRF). Fourteen years later, DSM-IV diagnoses were assessed, and ratings of self-reported and parent-rated behavioral and emotional problems were obtained. Results: CBCL and TRF scores predicted most of the outcomes, but in general, discrepancies between CBCL and TRF scores did not. There were some exceptions. For instance, higher parental vs. teacher ratings of aggressive behaviors increased the risk of suicide attempts/self-mutilation. Conclusion: Risk factors for self-mutilating behaviors may be supplemented with parent-reported aggressive behaviors that are not observed by the teachers. In general, whereas CBCL and TRF scale scores were useful predictors of outcome, parent-teacher discrepancies were not. </description>
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      <title>Ethnic disparities in problem behaviour in adolescence contribute to ethnic disparities in social class in adulthood (Article)</title>
      <link>http://repub.eur.nl/res/pub/36531/</link>
      <pubDate>2007-01-01T00:00:00Z</pubDate>
      <description>Background: It is important for prevention of social class disparities to know how ethnic disparities in social class arise among migrant children. We contribute to this understanding by examining the role of problem behaviour in adolescence. Methods: Prospective observational study with 753 Dutch native and 217 Turkish migrant adolescents (11-18 year) followed for 10 years. Internalising and externalising problems were assessed in adolescence and employment status and occupational level were assessed in adulthood. The difference in odds ratios (OR) before and after adjustment for internalising and externalising problems was an indication of the predictive value of disparities in internalising and externalising problems for the development of social class disparities. Results: A total of 135 (62%) of the Turkish and 602 (80%) of the Dutch adults were employed. Internalising and externalising problems were not associated with employment status. Of the employed, 65 (48%) Turkish and 179 (30%) Dutch adults worked in low-level occupations (p &lt; 0.0001). Internalising and externalising problems were associated with both ethnicity and occupation. The OR for low-level occupation for Turkish adults was 1.78 (1.19-2.65), indicating ethnic disparities. Adjustment for internalising problems lowered the OR with 36% to 1.50 (0.97-2.31), and adjustment for externalising problems lowered it with 8% to 1.72 (1.15-2.57). Findings were similar for men and women and did not vary by age. Conclusions: Ethnic disparities in occupational level in adulthood could partly be attributed to disparities in mental health between Turkish migrants and Dutch natives in adolescence. Prevention of ethnic disparities in mental health at young age may therefore also contribute to the prevention of occupational differences in adulthood. </description>
    </item> <item>
      <title>Symptoms of anxiety and depression in childhood and use of MDMA: prospective, population based study (Article)</title>
      <link>http://repub.eur.nl/res/pub/8259/</link>
      <pubDate>2006-01-01T00:00:00Z</pubDate>
      <description>OBJECTIVE: To investigate whether using ecstasy
      (3,4-methylenedioxymethamphetamine, MDMA) is preceded by symptoms of
      behavioural and emotional problems in childhood and early adolescence.
      DESIGN: Prospective, longitudinal, population based study SETTING: The
      Dutch province of Zuid-Holland. PARTICIPANTS: A sample of 1580
      individuals, followed up across a 14 year period, from childhood into
      adulthood. MAIN OUTCOME MEASURES: The first assessment took place in 1983
      before MDMA appeared as a recreational drug in the Netherlands and
      included the child behaviour checklist to obtain standardised parents'
      reports of their children's behavioural and emotional problems. Use of the
      drug was assessed with the composite international diagnostic interview 14
      years later. RESULTS: Eight syndrome scales of childhood behaviour were
      examined. Scores in the deviant range for the scales designated as anxious
      or depressed in childhood were significantly related to use of MDMA in
      adolescents and adults, resulting in an increased risk (hazard ratio 2.22,
      95% confidence interval 1.20 to 4.11, P = 0.01). CONCLUSIONS: Individuals
      with childhood symptoms of anxiety and depression may have an increased
      tendency to use MDMA in adolescence or young adulthood. Its effects are
      supposed to include enhanced feelings of bonding with other people,
      euphoria, or relaxation. Especially individuals with symptoms of anxiety
      or depression may be susceptible to these positive effects.</description>
    </item> <item>
      <title>Psychiatric disorders in young adult intercountry adoptees: an epidemiological study. (Article)</title>
      <link>http://repub.eur.nl/res/pub/13706/</link>
      <pubDate>2005-03-01T00:00:00Z</pubDate>
      <description>OBJECTIVE: The prevalences of psychiatric disorders in young adult intercountry adoptees and nonadopted young adults from the general population were compared. METHOD: In the Netherlands, a total of 1,484 young adult intercountry adoptees (72.5% of the original sample at age 10-15 years) and 695 nonadopted subjects (78.1% of the original sample) of comparable age from the general population were interviewed by using a standardized psychiatric interview generating DSM-IV diagnoses. RESULTS: The adopted young adults were 1.52 times as likely to meet the criteria for an anxiety disorder as the nonadopted young adults; the 95% confidence interval (CI) was 1.15-2.00. The adoptees were 2.05 (95% CI=1.32-3.17) times as likely to meet the criteria for substance abuse or dependence. The adopted men were 3.76 (95% CI=1.69-8.37) times as likely to have a mood disorder as nonadopted men, while for women there was no significant difference between adoptees and nonadoptees. No significant difference for the diagnosis of disruptive disorder was found. For all diagnoses together, adoptees with low and middle parental socioeconomic status in childhood did not differ from the comparison subjects, while adoptees with high parental socioeconomic status were 2.17 times (95% CI=1.50-3.13) as likely to meet the criteria for a disorder as nonadoptees with high parental socioeconomic status. CONCLUSIONS: Intercountry adoptees run a higher risk of having severe mental health problems in adulthood than nonadoptees of the same age. The risk of later malfunctioning differs for different disorders and different groups of adoptees.</description>
    </item> <item>
      <title>Stable prediction of mood and anxiety disorders based on behavioral and emotional problems in childhood: a 14-year follow-up during childhood, adolescence, and young adulthood (Article)</title>
      <link>http://repub.eur.nl/res/pub/10246/</link>
      <pubDate>2003-01-01T00:00:00Z</pubDate>
      <description>OBJECTIVE: The goal of this study was to predict the onset of mood and
      anxiety disorders from parent-reported emotional and behavioral problems
      in childhood across a 14-year period from childhood into young adulthood.
      METHOD: In 1983, parent reports of behavioral and emotional problems were
      obtained with the Child Behavior Checklist for children and adolescents
      4-16 years of age from the Dutch general population. At follow-up 14 years
      later, lifetime mood and anxiety diagnoses were obtained by a standardized
      DSM-IV interview for 1,580 subjects. Cox proportional hazards models were
      used to predict the incidence of mood and anxiety disorders from childhood
      problems and demographic covariates. RESULTS: Mood disorders were
      significantly predicted by high scores on the anxious/depressed scale and
      on the internalizing composite (withdrawn, somatic complaints, and
      anxious/depressed). Anxiety disorders were significantly predicted by the
      social problems scale and the externalizing composite (delinquent behavior
      and aggressive behavior). Anxiety disorders predominantly started in
      childhood and early adolescence, whereas the incidence of mood disorders
      increased sharply in adolescence and young adulthood. CONCLUSIONS: These
      results suggest different developmental pathways for mood and anxiety
      disorders. The predictions based on problem behavior remained stable
      during the 14-year period across adolescence and young adulthood. The
      results therefore underline the importance of early intervention and
      prevention of behavioral and emotional problems in childhood.</description>
    </item> <item>
      <title>Pathways of self-reported problem behaviors from adolescence into adulthood (Article)</title>
      <link>http://repub.eur.nl/res/pub/9861/</link>
      <pubDate>2002-01-01T00:00:00Z</pubDate>
      <description>OBJECTIVE: The authors determined the impact of different pathways of
      psychopathological development on adult outcome in subjects followed from
      ages 11-18 to ages 21-28. METHOD: Problem behaviors of subjects from a
      general population sample were assessed through the Youth Self-Report and
      the Young Adult Self-Report given at four time points (1987, 1989, 1991,
      and 1997). In addition, DSM-IV diagnoses, information pertaining to signs
      of maladjustment, and measures of social functioning were obtained at the
      last assessment. On the basis of the self-report ratings, four contrasting
      developmental pathways of psychopathology were determined: persistent,
      decreasing, increasing, and consistently normal. RESULTS: Subjects whose
      overall level of psychopathology was persistent over time had a higher
      lifetime prevalence of DSM-IV diagnoses and a poorer general outcome in
      adulthood than did subjects whose level of psychopathology increased.
      Subjects whose level of psychopathology returned to normal after high
      levels of problems in adolescence were only slightly different in terms of
      outcome from subjects with consistently normal ratings. CONCLUSIONS: 1)
      People who showed high levels of problems in early adolescence but whose
      level of psychopathology diminished by adulthood seemed to be as healthy
      as people who never attained a serious level of psychopathology. 2) An
      ongoing devious pathway into adulthood had negative effects on many
      domains of functioning. These two findings are both powerful arguments for
      early intervention in adolescence.</description>
    </item> <item>
      <title>Adolescents' self-reported problems as predictors of psychopathology in adulthood: 10-year follow-up study (Article)</title>
      <link>http://repub.eur.nl/res/pub/9733/</link>
      <pubDate>2001-01-01T00:00:00Z</pubDate>
      <description>BACKGROUND: Knowledge of the course of psychopathology from adolescence
      into adulthood is needed to answer questions concerning origins and
      prognosis of psychopathology across a wide age range. AIMS: To investigate
      the 10-year course and predictive value of self-reported problems in
      adolescence in relation to psychopathology in adulthood. METHOD: Subjects
      from the general population, aged 11-19 years, were assessed with the
      Youth Self-Report (YSR) at initial assessment, and with the Young Adult
      Self-Report (YASR), the Composite International Diagnostic Interview
      (CIDI) and three sections of the Diagnostic Interview Schedule (DIS) 10
      years later. RESULTS: Of the subjects with deviant YSR total problem
      scores, 23% (males) and 22% (females) had deviant YASR total problem
      scores at follow-up. Subjects with initial deviant YSR total problem,
      internalising and externalising scores had higher prevalences of DSM-IV
      diagnoses at follow-up. CONCLUSIONS: Adolescent problems tended to persist
      into adulthood to a moderate degree. High rates of problems during
      adolescence are risk factors for psychiatric disorders in adulthood.</description>
    </item> <item>
      <title>Predictors of psychopathology in young adults referred to mental health services in childhood or adolescence (Article)</title>
      <link>http://repub.eur.nl/res/pub/9441/</link>
      <pubDate>2000-01-01T00:00:00Z</pubDate>
      <description>BACKGROUND: For children referred to mental health services future
          functioning may be hampered. AIMS: To examine stability and prediction of
          behavioural and emotional problems from childhood into adulthood. METHOD:
          A referred sample (n = 789) aged 4-18 years was followed up after a mean
          of 10.5 years. Scores derived from the Child Behavior Checklist, Youth
          Self-Report and Teacher Report Form were related to equivalent scores for
          young adults from the Young Adult Self-Report and Young Adult Behavior
          Checklist. RESULTS: Correlations between first contact (T1) and follow-up
          (T2) scores were 0.12-0.53. Young adult psychopathology was predicted by
          corresponding T1 problem scores. Social problems and anxious/depressed
          scores were predictors of general problem behaviour. CONCLUSIONS: Problem
          behaviour of children and adolescents referred to outpatient mental health
          services is highly predictive of similar problem behaviour at young
          adulthood. Stability is higher for externalizing than for internalizing
          behaviour and for intra-informant than for inter-informant information.
          Stabilities are similar across gender. To obtain a comprehensive picture
          of the young adult's functioning, information from related adults may
          prove valuable.</description>
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