Brynes, R.K.

receptor g-csf patient g-csf receptor mutation neutropenia myeloid leukemia myeloid leukemia granulocyte colony-stimulating factor g-csf receptors wild-type copyright 1995 massachusetts factor response point mutation granulocyte product 32 d.wt cells colony-stimulating point cytoplasmic maturation domain pcr product pcr products region marrow blood c-terminal cytoplasmic region patient 2 point mutations wild-type receptor vector leukemic cells bone marrow cells expression panel g-csfreceptor signal c-terminal patients 1 clone medium neutropenic phase .2 cells protein digestion myeloid progenitor cells 8 g-csfreceptor mutations proliferation position analysis nucleotide phase myelodysplastic syndrome panel b culture proliferative genomic dna erasmu g-csf therapy interleukin neutrophil count society 32 d.wt treatment myeloperoxidase staining restriction www.nejm.org universiteit primers leukemic percent syndrome december biblio agranulocytosis progenitor number